Arribas, S M
Costa, R
Salomone, S.
Morel, Nicole
[UCL]
Godfraind, Theophile
[UCL]
McGrath, J C
The stroke-prone spontaneously hypertensive rat (SHRSP) is a strain with high incidence of cerebrovascular accidents increased by salt-rich diet and decreased by calcium-antagonist treatment. In the SHRSP rat basilar artery the authors have previously shown reduced contractility and altered structure including regions of smooth muscle cell (SMC) disorganization. The aims of this study have been to analyze (1) the morphology of these abnormal regions, (2) the structural modifications responsible for the reduced function, and (3) the effect of salt and calcium-antagonist treatment on vascular structure and function. Wistar Kyoto and SHRSP rats, untreated or treated from week 8 through 14 with 1% NaCl or 1% NaCl + 1 mg x kg(-1) x d(-1) lacidipine, were used. Function was studied with wire myography. Structure was analyzed in fixed intact arteries with confocal microscopy. Basilar arteries from SHRSP rat showed (1) reduced contractility, (2) discrete foci of SMC disarray with altered proportion of adventitia to SMC, and (3) decreased SMC and increased adventitial cell number. Arteries from salt-loaded SHRSP rats showed a higher degree of SMC disarray and further reduction in contractility. Lacidipine treatment of salt-loaded rats significantly improved structure and function. These data suggest that vascular remodeling can provide an explanation for the observed reduction in vascular contractility of SHRSP rat basilar arteries and might show light on the effects of salt load and calcium-channel blockers in life span and the incidence of cerebrovascular accidents in SHRSP rats.
- Arribas S. M., Daly C. J., Gordon J. F., McGrath J. C., Confocal Myography: Applications for the Study of Resistance Arteries, The Resistance Arteries (1994) ISBN:9781617370083 p.259-264, 10.1007/978-1-4757-2296-3_24
- Arribas S. M., Gordon J. F., Daly C. J., Dominiczak A. F., McGrath J. C., Confocal Microscopic Characterization of a Lesion in a Cerebral Vessel of the Stroke-Prone Spontaneously Hypertensive Rat, 10.1161/01.str.27.6.1118
- Arribas SM, J Hypertens, 14, S264 (1996)
- Arribas S. M., Hillier C., Gonzalez C., McGrory S., Dominiczak A. F., McGrath J. C., Cellular Aspects of Vascular Remodeling in Hypertension Revealed by Confocal Microscopy, 10.1161/01.hyp.30.6.1455
- Arribas Silvia M., González Carmen, Graham Delyth, Dominiczak Anna F., McGrath John C., Cellular changes induced by chronic nitric oxide inhibition in intact rat basilar arteries revealed by confocal microscopy : , 10.1097/00004872-199715120-00073
- Hunter Steven J., Harper Roy, Ennis Cieran N., Crothers Elizabeth, Sheridan Brian, Johnston G Dennis, Atkinson A Brew, Bell Patrick M., Effects of combination therapy with an angiotensin converting enzyme inhibitor and thiazide diuretic on insulin action in essential hypertension : , 10.1097/00004872-199816010-00015
- Ashen M. D., Hamlyn J. M., Smooth Muscle Hypertrophy and Arterial Remodelling in Deoxycorticosterone Acetate-Salt Hypertension, 10.3109/10641969409072216
- Baumbach G. L., Heistad D. D., Remodeling of cerebral arterioles in chronic hypertension., 10.1161/01.hyp.13.6.968
- Contard F., Sabri A., Glukhova M., Sartore S., Marotte F., Pomies J. P., Schiavi P., Guez D., Samuel J. L., Rappaport L., Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats, 10.1161/01.hyp.22.5.665
- De Mey JGR, Blood Vessels, 28, 372 (1991)
- Feron O., Salomone S., Godfraind T., Inhibition by Lacidipine of Salt-Dependent Cardiac Hypertrophy and Endothelin Gene Expression in Stroke-Prone Spontaneously Hypertensive Rats, 10.1006/bbrc.1995.1649
- Folkow B., "Structural factor" in primary and secondary hypertension., 10.1161/01.hyp.16.1.89
- Fredriksson K., Auer R. N., Kalimo H., Nordborg C., Olsson Y., Johansson B. B., Cerebrovascular lesions in stroke-prone spontaneously hypertensive rats, 10.1007/bf00690831
- Gaviraghi G., Godfraind T., New Insight into the Vascular Properties of Lacidipine, Calcium Antagonists (1993) ISBN:9789401047562 p.65-69, 10.1007/978-94-011-1725-8_10
- Gries Josef, Kretzschmar Rolf, Neumann B. Wolfgang, Development of Hypertension and Life Span in Stroke-Prone Spontaneously Hypertensive Rats During Oral Long-Term Treatment with Various Antihypertensive Drugs : , 10.1097/00005344-198900134-00024
- Hajdu M, Am J Physiol, 266, H1027 (1994)
- Kondo S., Hashimoto N., Kikuchi H., Hazama F., Nagata I., Kataoka H., Rosenblum W. I., Apoptosis of Medial Smooth Muscle Cells in the Development of Saccular Cerebral Aneurysms in Rats Editorial Comment, 10.1161/01.str.29.1.181
- Korner PI, Hypertension, 29, 1065 (1997)
- Lee RMKW, J Hypertens, 14, S29 (1996)
- Lee RMKW, J Hypertension, 15, 333 (1996)
- Mulvany M. J., Halpern W., Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats, 10.1161/01.res.41.1.19
- Mulvany M. J., Hansen O. K., Aalkjaer C., Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers, 10.1161/01.res.43.6.854
- Mulvany M. J., Aalkjaer C., Christensen J., Changes in noradrenaline sensitivity and morphology of arterial resistance vessels during development of high blood pressure in spontaneously hypertensive rats, 10.1161/01.hyp.2.5.664
- Mulvany MJ, Hypertension, 28, 505 (1996)
- Ogata Jun, Fujishima Masatoshi, Tamaki Kinya, Nakatomi Yasuo, Ishitsuka Takao, Omae Teruo, Stroke-prone spontaneously hypertensive rats as an experimental model of malignant hypertension : I. A light- and electron-microscopic study of the brain, 10.1007/bf00687384
- ARCHIE J. P., FIXLER D. E., ULLYOT D. J., BUCKBERG G. D., HOFFMAN J. I. E., Regional Myocardial Blood Flow in Lambs with Concentric Right Ventricular Hypertrophy, 10.1161/01.res.34.2.143
- Rhodin JAG, Handbook of Physiology. The Cardiovascular System, 2, 1 (1980)
- Salomone Salvatore, Morel Nicole, Godfraind Théophile, Role of nitric oxide in the contractile response to 5-hydroxytryptamine of the basilar artery from Wistar Kyoto and stroke-prone rats, 10.1038/sj.bjp.0701227
- Schiffrin EL, Hypertension, 9, II-1-II (1992)
- Scott-Burden Timothy, Resink Thérèse J., Bühler Fritz R., Enhanced Growth and Growth Factor Responsiveness of Vascular Smooth Muscle Cells from Hypertensive Rats : , 10.1097/00005344-198906146-00006
- Shi Y., Pieniek M., Fard A., O'Brien J., Mannion J. D., Zalewski A., Adventitial Remodeling After Coronary Arterial Injury, 10.1161/01.cir.93.2.340
- Shinyama H, J Pharmacol Exp Ther, 272, 911 (1995)
- Smeda John S., Cerebral vascular changes associated with hemorrhagic stroke in hypertension, 10.1139/y92-070
- Takakura S., Furuichi Y., Yamamoto T., Ogawa T., Satoh H., Mori J., Effect of nilvadipine on the development of neurological deficits in stroke-prone spontaneously hypertensive rats, 10.1161/01.str.25.3.677
- Thyberg J., Hedin U., Sjolund M., Palmberg L., Bottger B. A., Regulation of differentiated properties and proliferation of arterial smooth muscle cells, 10.1161/01.atv.10.6.966
- Traub Oren, Lloyd Mary C., Webb R. Clinton, Long-term effects of brief antihypertensive treatment on systolic blood pressure and vascular reactivity in young genetically hypertensive rats, 10.1007/bf00879031
- Vacher Elisabeth, Richer Christine, Giudicelli Jean-Fran??ois, Effects of losartan on cerebral arteries in stroke-prone spontaneously hypertensive rats : , 10.1097/00004872-199611000-00013
- Vacher Elisabeth, Richer Christine, Fornes Paul, Clozel Jean-Paul, Giudicelli Jean-François, Mibefradil, a Selective Calcium T-Channel Blocker, in Stroke-Prone Spontaneously Hypertensive Rats : , 10.1097/00005344-199605000-00011
- Volpe M, Iaccarino G, Vecchione C, Rizzoni D, Russo R, Rubattu S, Condorelli G, Ganten U, Ganten D, Trimarco B, Lindpaintner K, Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats., 10.1172/jci118787
- YAMORI YUKIO, HORIE RYOICHI, AKIGUCHI ICHIRO, KIHARA MASAHIRO, NARA YASUO, LOVENBERG WALTER, Symptomatological classification in the development of stroke in stroke-prone spontaneously hypertensive rats., 10.1253/jcj.46.274
Référence bibliographique |
Arribas, S M ; Costa, R ; Salomone, S. ; Morel, Nicole ; Godfraind, Theophile ; et. al. Functional reduction and associated cellular rearrangement in SHRSP rat basilar arteries are affected by salt load and calcium antagonist treatment.. In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 19, no. 5, p. 517-27 (1999) |
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http://hdl.handle.net/2078.1/21849 |