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Functional reduction and associated cellular rearrangement in SHRSP rat basilar arteries are affected by salt load and calcium antagonist treatment.

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Arribas, S M Costa, R Salomone, S. Morel, Nicole [UCL] Godfraind, Theophile [UCL] McGrath, J C

The stroke-prone spontaneously hypertensive rat (SHRSP) is a strain with high incidence of cerebrovascular accidents increased by salt-rich diet and decreased by calcium-antagonist treatment. In the SHRSP rat basilar artery the authors have previously shown reduced contractility and altered structure including regions of smooth muscle cell (SMC) disorganization. The aims of this study have been to analyze (1) the morphology of these abnormal regions, (2) the structural modifications responsible for the reduced function, and (3) the effect of salt and calcium-antagonist treatment on vascular structure and function. Wistar Kyoto and SHRSP rats, untreated or treated from week 8 through 14 with 1% NaCl or 1% NaCl + 1 mg x kg(-1) x d(-1) lacidipine, were used. Function was studied with wire myography. Structure was analyzed in fixed intact arteries with confocal microscopy. Basilar arteries from SHRSP rat showed (1) reduced contractility, (2) discrete foci of SMC disarray with altered proportion of adventitia to SMC, and (3) decreased SMC and increased adventitial cell number. Arteries from salt-loaded SHRSP rats showed a higher degree of SMC disarray and further reduction in contractility. Lacidipine treatment of salt-loaded rats significantly improved structure and function. These data suggest that vascular remodeling can provide an explanation for the observed reduction in vascular contractility of SHRSP rat basilar arteries and might show light on the effects of salt load and calcium-channel blockers in life span and the incidence of cerebrovascular accidents in SHRSP rats.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1999
Journal information "Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism" - Vol. 19, no. 5, p. 517-27 (1999)
Peer reviewed yes
issn 0271-678X
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Animals ; Antihypertensive Agents - therapeutic use ; Basilar Artery - pathology ; Calcium Channel Blockers - therapeutic use ; Cerebrovascular Disorders - genetics ; Dihydropyridines - therapeutic use ; Genetic Predisposition to Disease ; Hypertension - complications ; Microscopy, Confocal ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Sodium Chloride, Dietary - adverse effects
Links
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Bibliographic reference Arribas, S M ; Costa, R ; Salomone, S. ; Morel, Nicole ; Godfraind, Theophile ; et. al. Functional reduction and associated cellular rearrangement in SHRSP rat basilar arteries are affected by salt load and calcium antagonist treatment.. In: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 19, no. 5, p. 517-27 (1999)
Permanent URL http://hdl.handle.net/2078.1/21849