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Serum beta-carotene in anorexia nervosa patients: a case-control study.

Onglets principaux

Boland, Benoît [UCL] Beguin, Claire [UCL] Zech, Francis [UCL] Desager, Jean-Pierre [UCL] Lambert, Michel [UCL]

OBJECTIVE: To study the prevalence of hypercarotenemia in a large cohort of patients with anorexia nervosa (AN), to compare serum beta-carotene (betaC) values among restricting and purging AN subjects, and to investigate whether hypercarotenemia is related to an increase in low-density lipoprotein (LDL) cholesterol. METHOD: Retrospective case-control study including 101 female patients and 95 age-matched normal controls in whom fasting serum betaC and lipid profiles were determined. RESULTS: The prevalence of hypercarotenemia (>200 microg/dl) in the AN population was 62%. Mean serum betaC level was significantly higher in AN patients than in controls (237 +/- 103 vs. 160 +/- 45 microg/dl, p <.0001). Among AN patients, the level was higher in restricters than in purgers (271 +/- 110 vs. 186 +/- 78 microg/dl, p <.005). Fasting serum total and LDL cholesterol levels were also significantly higher in patients with AN than in controls, but no correlation was found between serum betaC and LDL cholesterol values. DISCUSSION: Hypercarotenemia is a common finding in AN patients, especially in the restricter subgroup. The high prevalence of elevated serum betaC in AN patients supports its diagnostic value in atypical forms of eating disorders.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès restreint
Année de publication 2001
Information sur le périodique "International Journal of Eating Disorders" - Vol. 30, no. 3, p. 299-305 (2001)
Peer reviewed oui
Editeur JohnWiley & Sons, Inc. (Hoboken)
issn 0276-3478
e-issn 1098-108X
Statut de la publication Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de gériatrie
UCL - (SLuc) Service de médecine interne et maladies infectieuses (MIMI)
MESH Subject Adult ; Anorexia Nervosa - complications - diagnosis ; Biological Markers - blood ; Case-Control Studies ; Cholesterol, LDL - blood ; Diet, Reducing ; Female ; Humans ; Hypercholesterolemia - etiology - physiopathology ; Prevalence ; Retrospective Studies ; beta Carotene - blood
Mots-clés Hypercarotenemia ; Anorexia nervosa ; Serum beta-carotene
Liens
  1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed). Washington, DC: Author.
  2. Bhanji S., Mattingly D., Anorexia nervosa: some observations on "dieters" and "vomiters", cholesterol and carotene, 10.1192/bjp.139.3.238
  3. & (1988). Cholesterol and carotene. In & (Eds.), Medical aspects of anorexia nervosa (pp. 86-91). London: Wright.
  4. & (1968). Bray's clinical laboratory methods. St. Louis, MO: Mosby.
  5. Becker Anne E., Grinspoon Steven K., Klibanski Anne, Herzog David B., Eating Disorders, 10.1056/nejm199904083401407
  6. Casper R C, The Pathophysiology of Anorexia Nervosa and Bulimia Nervosa, 10.1146/annurev.nu.06.070186.001503
  7. Curran-Celentano, American Journal of Clinical Nutrition, 42, 1183 (1985)
  8. Dally P. J., Carotenaemia Occurring in a Case of Anorexia Nervosa, 10.1136/bmj.1.5133.1333
  9. Friedewald, Clinical Chemistry, 18, 499 (1972)
  10. Frumar Anthony M., Meldrum David R., Judd Howard L., Hypercarotenemia in Hypothalamic Amenorrhea**Supported by Grant CA 23093 from the United States Public Health Service., 10.1016/s0015-0282(16)44229-9
  11. Kemmann Ekkehard, Amenorrhea Associated With Carotenemia, 10.1001/jama.1983.03330310056029
  12. Lambert Michel, Hubert Catherine, Depresseux Genevi�ve, Vande Berg Bruno, Thissen Jean-Paul, de Deuxchaisnes Charles Nagant, Devogelaer Jean-Pierre, Hematological changes in anorexia nervosa are correlated with total body fat mass depletion, 10.1002/(sici)1098-108x(1997)21:4<329::aid-eat4>3.0.co;2-q
  13. Lopes-Virella, Clinical Chemistry, 23, 882 (1977)
  14. Mehler Philip S., Lezotte Dennis, Eckel Robert, Lipid levels in anorexia nervosa, 10.1002/(sici)1098-108x(199809)24:2<217::aid-eat11>3.0.co;2-w
  15. Pops, Journal of the American Medical Association, 205, 121 (1968)
  16. Robboy, American Journal of Clinical Nutrition, 27, 362 (1974)
  17. Rock Cheryl L., Curran-Celentano Joanne, Nutritional disorder of anorexia nervosa: A review, 10.1002/1098-108x(199403)15:2<187::aid-eat2260150210>3.0.co;2-f
  18. Rock, American Journal of Clinical Nutrition, 64, 566 (1996)
  19. Rock Cheryl L., Swendseid Marian E., [12] Plasma carotenoid levels in anorexia nervosa and in obese patients, Methods in Enzymology (1993) ISBN:9780121821159 p.116-123, 10.1016/0076-6879(93)14059-r
  20. SCHWABE ARTHUR D., Anorexia Nervosa, 10.7326/0003-4819-94-3-371
  21. Sherman Philip, Leslie Karen, Goldberg Eudice, Rybczynski Julietta, Louis Patrick St., Hypercarotenemia and transaminitis in female adolescents with eating disorders: A prospective, controlled study, 10.1016/1054-139x(94)90505-3
Référence bibliographique Boland, Benoît ; Beguin, Claire ; Zech, Francis ; Desager, Jean-Pierre ; Lambert, Michel. Serum beta-carotene in anorexia nervosa patients: a case-control study.. In: International Journal of Eating Disorders, Vol. 30, no. 3, p. 299-305 (2001)
Permalien http://hdl.handle.net/2078.1/24042