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Linking Cell Polarity to Cortical Development and Malformations.

Onglets principaux

Hakanen, Janne Ruiz-Reig, Nuria Tissir, Fadel [UCL]

Cell polarity refers to the asymmetric distribution of signaling molecules, cellular organelles, and cytoskeleton in a cell. Neural progenitors and neurons are highly polarized cells in which the cell membrane and cytoplasmic components are compartmentalized into distinct functional domains in response to internal and external cues that coordinate polarity and behavior during development and disease. In neural progenitor cells, polarity has a prominent impact on cell shape and coordinate several processes such as adhesion, division, and fate determination. Polarity also accompanies a neuron from the beginning until the end of its life. It is essential for development and later functionality of neuronal circuitries. During development, polarity governs transitions between multipolar and bipolar during migration of postmitotic neurons, and directs the specification and directional growth of axons. Once reaching final positions in cortical layers, neurons form dendrites which become compartmentalized to ensure proper establishment of neuronal connections and signaling. Changes in neuronal polarity induce signaling cascades that regulate cytoskeletal changes, as well as mRNA, protein, and vesicle trafficking, required for synapses to form and function. Hence, defects in establishing and maintaining cell polarity are associated with several neural disorders such as microcephaly, lissencephaly, schizophrenia, autism, and epilepsy. In this review we summarize the role of polarity genes in cortical development and emphasize the relationship between polarity dysfunctions and cortical malformations.

Type de document Article de périodique (Journal article)
Année de publication 2019
Langue Anglais
Information sur le périodique "Frontiers in cellular neuroscience" - Vol. 13, p. 244 (2019)
Peer reviewed oui
issn 1662-5102
Statut de la publication Publié
Affiliations UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire
Mots-clés axon and dendrite polarization ; axon growth and guidance ; neurogenesis ; neuronal migration anomalies ; synapse formation
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Référence bibliographique Hakanen, Janne ; Ruiz-Reig, Nuria ; Tissir, Fadel. Linking Cell Polarity to Cortical Development and Malformations.. In: Frontiers in cellular neuroscience, Vol. 13, p. 244 (2019)
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