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Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia.

Onglets principaux

Cahu, Xavier [UCL] Carré, Martin Recher, Christian Pigneux, Arnaud Hunault-Berger, Mathilde Cahn, Jean-Yves

OBJECTIVES: Anthracyclines and cytarabine are cornerstones for intensive chemotherapy in acute myeloid leukemia (AML). The goals of this study were to comprehensively assess deviations from theoretical doses and the impact of body-surface area (BSA) on patients' characteristics, physicians' strategy, dose adjustment, and clinical outcome. METHODS: The GOELAMS 2001 phase III trial included 823 AML patients below 60 years of age. In the course of treatment, anthropomorphic parameters and chemotherapy doses were prospectively registered. RESULTS: Very high BSA (≥2.15 m2 ) was the factor most significantly associated with the physician's decision to reduce chemotherapy doses during induction and postremission therapy. Despite similar AML characteristics and therapeutic strategies, the very high BSA group exhibited a significantly worse survival (5-years OS of 27%) compared to the low (BSA≤1.5 m2 ), intermediate (1.5 m2

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès restreint
Année de publication 2017
Langue Anglais
Information sur le périodique "European Journal of Haematology" - Vol. 98, no.5, p. 443-449 (2017)
Peer reviewed oui
Editeur Wiley-Blackwell Publishing, Inc. ((United Kingdom) Oxford)
issn 0902-4441
e-issn 1600-0609
Statut de la publication Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
UCL - SSS/DDUV/SIGN - Cell signalling
MESH Subject Adult ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols ; Body Surface Area ; Body Weights and Measures ; Clinical Trials, Phase III as Topic ; Female ; Humans ; Leukemia, Myeloid, Acute ; Male ; Multicenter Studies as Topic ; Recurrence ; Remission Induction ; Survival Analysis ; Treatment Outcome ; Young Adult
Mots-clés acute myeloid leukemia ; body-surface area ; dose intensity ; dose reduction
Liens
  1. Dohner H., Estey E. H., Amadori S., Appelbaum F. R., Buchner T., Burnett A. K., Dombret H., Fenaux P., Grimwade D., Larson R. A., Lo-Coco F., Naoe T., Niederwieser D., Ossenkoppele G. J., Sanz M. A., Sierra J., Tallman M. S., Lowenberg B., Bloomfield C. D., Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet, 10.1182/blood-2009-07-235358
  2. Fernandez Hugo F., Sun Zhuoxin, Yao Xiaopan, Litzow Mark R., Luger Selina M., Paietta Elisabeth M., Racevskis Janis, Dewald Gordon W., Ketterling Rhett P., Bennett John M., Rowe Jacob M., Lazarus Hillard M., Tallman Martin S., Anthracycline Dose Intensification in Acute Myeloid Leukemia, 10.1056/nejmoa0904544
  3. Burnett Alan K., Russell Nigel H., Hills Robert K., Kell Jonathan, Cavenagh Jamie, Kjeldsen Lars, McMullin Mary-Frances, Cahalin Paul, Dennis Mike, Friis Lone, Thomas Ian F., Milligan Don, Clark Richard E., A randomized comparison of daunorubicin 90 mg/m 2 vs 60 mg/m 2 in AML induction: results from the UK NCRI AML17 trial in 1206 patients , 10.1182/blood-2015-01-623447
  4. Lee J.-H., Joo Y.-D., Kim H., Bae S. H., Kim M. K., Zang D. Y., Lee J.-L., Lee G. W., Lee J.-H., Park J.-H., Kim D.-Y., Lee W.-S., Ryoo H. M., Hyun M. S., Kim H. J., Min Y. J., Jang Y.-E., Lee K.-H., , A randomized trial comparing standard versus high-dose daunorubicin induction in patients with acute myeloid leukemia, 10.1182/blood-2011-06-361410
  5. Griggs Jennifer J., Mangu Pamela B., Anderson Holly, Balaban Edward P., Dignam James J., Hryniuk William M., Morrison Vicki A., Pini T. May, Runowicz Carolyn D., Rosner Gary L., Shayne Michelle, Sparreboom Alex, Sucheston Lara E., Lyman Gary H., Appropriate Chemotherapy Dosing for Obese Adult Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline, 10.1200/jco.2011.39.9436
  6. Ng Marie, Fleming Tom, Robinson Margaret, Thomson Blake, Graetz Nicholas, Margono Christopher, Mullany Erin C, Biryukov Stan, Abbafati Cristiana, Abera Semaw Ferede, Abraham Jerry P, Abu-Rmeileh Niveen M E, Achoki Tom, AlBuhairan Fadia S, Alemu Zewdie A, Alfonso Rafael, Ali Mohammed K, Ali Raghib, Guzman Nelson Alvis, Ammar Walid, Anwari Palwasha, Banerjee Amitava, Barquera Simon, Basu Sanjay, Bennett Derrick A, Bhutta Zulfiqar, Blore Jed, Cabral Norberto, Nonato Ismael Campos, Chang Jung-Chen, Chowdhury Rajiv, Courville Karen J, Criqui Michael H, Cundiff David K, Dabhadkar Kaustubh C, Dandona Lalit, Davis Adrian, Dayama Anand, Dharmaratne Samath D, Ding Eric L, Durrani Adnan M, Esteghamati Alireza, Farzadfar Farshad, Fay Derek F J, Feigin Valery L, Flaxman Abraham, Forouzanfar Mohammad H, Goto Atsushi, Green Mark A, Gupta Rajeev, Hafezi-Nejad Nima, Hankey Graeme J, Harewood Heather C, Havmoeller Rasmus, Hay Simon, Hernandez Lucia, Husseini Abdullatif, Idrisov Bulat T, Ikeda Nayu, Islami Farhad, Jahangir Eiman, Jassal Simerjot K, Jee Sun Ha, Jeffreys Mona, Jonas Jost B, Kabagambe Edmond K, Khalifa Shams Eldin Ali Hassan, Kengne Andre Pascal, Khader Yousef Saleh, Khang Young-Ho, Kim Daniel, Kimokoti Ruth W, Kinge Jonas M, Kokubo Yoshihiro, Kosen Soewarta, Kwan Gene, Lai Taavi, Leinsalu Mall, Li Yichong, Liang Xiaofeng, Liu Shiwei, Logroscino Giancarlo, Lotufo Paulo A, Lu Yuan, Ma Jixiang, Mainoo Nana Kwaku, Mensah George A, Merriman Tony R, Mokdad Ali H, Moschandreas Joanna, Naghavi Mohsen, Naheed Aliya, Nand Devina, Narayan K M Venkat, Nelson Erica Leigh, Neuhouser Marian L, Nisar Muhammad Imran, Ohkubo Takayoshi, Oti Samuel O, Pedroza Andrea, Prabhakaran Dorairaj, Roy Nobhojit, Sampson Uchechukwu, Seo Hyeyoung, Sepanlou Sadaf G, Shibuya Kenji, Shiri Rahman, Shiue Ivy, Singh Gitanjali M, Singh Jasvinder A, Skirbekk Vegard, Stapelberg Nicolas J C, Sturua Lela, Sykes Bryan L, Tobias Martin, Tran Bach X, Trasande Leonardo, Toyoshima Hideaki, van de Vijver Steven, Vasankari Tommi J, Veerman J Lennert, Velasquez-Melendez Gustavo, Vlassov Vasiliy Victorovich, Vollset Stein Emil, Vos Theo, Wang Claire, Wang XiaoRong, Weiderpass Elisabete, Werdecker Andrea, Wright Jonathan L, Yang Y Claire, Yatsuya Hiroshi, Yoon Jihyun, Yoon Seok-Jun, Zhao Yong, Zhou Maigeng, Zhu Shankuan, Lopez Alan D, Murray Christopher J L, Gakidou Emmanuela, Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013, 10.1016/s0140-6736(14)60460-8
  7. Kempf Emmanuelle, Hirsch Pierre, Labopin Myriam, Viguié Frank, Isnard Françoise, Tang Ruoping, Marzac Christophe, Marie Jean Pierre, Mohty Mohamad, Legrand Ollivier, Prognosis of body mass index and chemotherapy dose capping in acute myeloid leukaemia, 10.1016/j.leukres.2014.09.013
  8. Wenzell Candice M., Gallagher Erika M., Earl Marc, Yeh Jun-Yen, Kusick Karissa N., Advani Anjali S., Kalaycio Matt E., Mukherjee Sudipto, Tiu Ramon V., Maciejewski Jaroslaw P., Sekeres Mikkael A., Outcomes in obese and overweight acute myeloid leukemia patients receiving chemotherapy dosed according to actual body weight, 10.1002/ajh.23530
  9. Sandhu G, Mapp S, Carrington C, Hennig S, To Cap or Not to Cap: Chemotherapy Dosing in Obese Adult Hematology Patients, 10.1038/clpt.2014.3
  10. Thompson Lisa A., Lawson Amber P., Sutphin Stephanie D., Steinke Douglas, Adams Val R., Description of Current Practices of Empiric Chemotherapy Dose Adjustment in Obese Adult Patients, 10.1200/jop.200016
  11. Peric Kaylene M., Reeves David J., Tolerability of induction chemotherapy dosing practices in acute myeloid leukemia patients, 10.1016/j.leukres.2014.11.024
  12. Tavitian Suzanne, Denis Amélia, Vergez François, Berard Emilie, Sarry Audrey, Huynh Anne, Delabesse Eric, Luquet Isabelle, Huguet Françoise, Récher Christian, Bertoli Sarah, Impact of obesity in favorable-risk AML patients receiving intensive chemotherapy : Impact of obesity in AML, 10.1002/ajh.24228
  13. Medeiros B. C., Othus M., Estey E. H., Fang M., Appelbaum F. R., Impact of body-mass index on the outcome of adult patients with acute myeloid leukemia, 10.3324/haematol.2011.056390
  14. Récher C, , Béné M C, Lioure B, Pigneux A, Vey N, Delaunay J, Luquet I, Hunault M, Guyotat D, Bouscary D, Fegueux N, Jourdan E, Lissandre S, Escoffre-Barbe M, Bonmati C, Randriamalala E, Guièze R, Ojeda-Uribe M, Dreyfus F, Harousseau J L, Cahn J Y, Ifrah N, Guardiola P, Long-term results of a randomized phase 3 trial comparing idarubicin and daunorubicin in younger patients with acute myeloid leukaemia, 10.1038/leu.2013.290
  15. Chevallier P, , Fornecker L, Lioure B, Béné M C, Pigneux A, Recher C, Witz B, Fegueux N, Bulabois C-E, Daliphard S, Bouscary D, Vey N, Delain M, Bay J-O, Turlure P, Bernard M, Himberlin C, Luquet I, Ifrah N, Harousseau J-L, Tandem versus single autologous peripheral blood stem cell transplantation as post-remission therapy in adult acute myeloid leukemia patients under 60 in first complete remission: results of the multicenter prospective phase III GOELAMS LAM-2001 trial, 10.1038/leu.2010.111
  16. Lioure B., Bene M. C., Pigneux A., Huynh A., Chevallier P., Fegueux N., Blaise D., Witz B., Delain M., Cornillon J., Luquet I., Blanchet O., Cornillet-Lefebvre P., Carre M., Hunault M., Larosa F., Lamy T., Randriamalala E., Ojeda-Uribe M., Berthou C., Fornecker L., Harousseau J.-L., Bouscary D., Ifrah N., Cahn J.-Y., , Early matched sibling hematopoietic cell transplantation for adult AML in first remission using an age-adapted strategy: long-term results of a prospective GOELAMS study, 10.1182/blood-2011-05-352989
  17. Du Bois, Nutrition, 5, 303 (1989)
  18. Lee Hun Ju, Licht Andrea S., Hyland Andrew J., Ford Laurie A., Sait Sheila N. J., Block AnneMarie W., Barcos Maurice, Baer Maria R., Wang Eunice S., Wetzler Meir, Is obesity a prognostic factor for acute myeloid leukemia outcome?, 10.1007/s00277-011-1319-8
  19. Lin Andrew, Othus Megan, McQuary Amy, Chi Mary, Estey Elihu, Influence of obesity on efficacy and toxicity of induction chemotherapy in patients with newly diagnosed acute myeloid leukemia, 10.3109/10428194.2012.717278
  20. Castillo Jorge J., Mulkey Flora, Geyer Susan, Kolitz Jonathan E., Blum William, Powell Bayard L., George Stephen L., Larson Richard A., Stone Richard M., Relationship between obesity and clinical outcome in adults with acute myeloid leukemia: A pooled analysis from four CALGB (alliance) clinical trials : Obesity APL AML Survival, 10.1002/ajh.24230
  21. Crysandt Martina, Kramer Michael, Ehninger Gerhard, Bornhäuser Martin, Berdel Wolfgang E., Serve Hubert, Röllig Christoph, Kaifie Andrea, Jost Edgar, Brummendorf Tim H., Wilop Stefan, A high BMI is a risk factor in younger patients withde novoacute myelogenous leukemia, 10.1111/ejh.12675
  22. Hanley Michael J., Abernethy Darrell R., Greenblatt David J., Effect of Obesity on the Pharmacokinetics of Drugs in Humans : , 10.2165/11318100-000000000-00000
  23. Morrish Glynn A, Pai Manjunath P, Green Bruce, The effects of obesity on drug pharmacokinetics in humans, 10.1517/17425255.2011.570331
  24. Sparreboom Alex, Wolff Antonio C., Mathijssen Ron H.J., Chatelut Etienne, Rowinsky Eric K., Verweij Jaap, Baker Sharyn D., Evaluation of Alternate Size Descriptors for Dose Calculation of Anticancer Drugs in the Obese, 10.1200/jco.2007.11.2938
  25. Green Bruce, Duffull Stephen B., What is the best size descriptor to use for pharmacokinetic studies in the obese?, 10.1111/j.1365-2125.2004.02157.x
  26. Douer Dan, Aldoss Ibrahim, Lunning Matthew A., Burke Patrick W., Ramezani Laleh, Mark Lisa, Vrona Janice, Park Jae H., Tallman Martin S., Avramis Vassilios I., Pullarkat Vinod, Mohrbacher Ann M., Pharmacokinetics-Based Integration of Multiple Doses of Intravenous Pegaspargase in a Pediatric Regimen for Adults With Newly Diagnosed Acute Lymphoblastic Leukemia, 10.1200/jco.2013.50.2708
Référence bibliographique Cahu, Xavier ; Carré, Martin ; Recher, Christian ; Pigneux, Arnaud ; Hunault-Berger, Mathilde ; et. al. Impact of body-surface area on patients' outcome in younger adults with acute myeloid leukemia.. In: European Journal of Haematology, Vol. 98, no.5, p. 443-449 (2017)
Permalien http://hdl.handle.net/2078.1/204038