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Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease.

Onglets principaux

Starkel, Peter [UCL] Leclercq, Sophie [UCL] de Timary, Philippe [UCL] Schnabl, Bernd

Alcohol dependence and alcoholic liver disease represent a major public health problem with substantial morbidity and mortality. By yet incompletely understood mechanisms, chronic alcohol abuse is associated with increased intestinal permeability and alterations of the gut microbiota composition, allowing bacterial components, bacteria, and metabolites to reach the portal and the systemic circulation. These gut-derived bacterial products are recognized by immune cells circulating in the blood or residing in remote organs such as the liver leading to the release of pro-inflammatory cytokines which are considered important mediators of the liver-gut-brain communication. Although circulating cytokines are likely not the sole factors involved, they can induce liver inflammation/damage and reach the central nervous system where they favor neuroinflammation which is associated with change in mood, cognition, and drinking behavior. In this review, the authors focus on the current evidence describing the changes that occur in the intestinal microbiota with chronic alcohol consumption in conjunction with intestinal barrier breakdown and inflammatory changes sustaining the concept of a gut-liver-brain axis in the pathophysiology of alcohol dependence and alcoholic liver disease.

Type de document Article de périodique (Journal article) – Article de recherche
Année de publication 2018
Langue Anglais
Information sur le périodique "Clinical Science" - Vol. 132, no. 2, p. 199-212 (2018)
Peer reviewed oui
Editeur Portland Press Ltd. ((United Kingdom) London)
issn 0143-5221
e-issn 1470-8736
Statut de la publication Publié
Affiliations UCL - SSS/IONS - Institute of NeuroScience
UCL - SSS/IONS/NEUR - Clinical Neuroscience
UCL - SSS/IREC/GAEN - Pôle d'Hépato-gastro-entérologie
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - (SLuc) Service d'hépato-gastro-entérologie
UCL - (SLuc) Service de psychiatrie adulte
Mots-clés alcohol dependence ; brain ; gut barrier ; inflammation ; liver disease ; microbiome
Liens
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Référence bibliographique Starkel, Peter ; Leclercq, Sophie ; de Timary, Philippe ; Schnabl, Bernd. Intestinal dysbiosis and permeability: the yin and yang in alcohol dependence and alcoholic liver disease.. In: Clinical Science, Vol. 132, no. 2, p. 199-212 (2018)
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