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Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers.

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Seys, Sven F Hox, Valérie [UCL] Van Gerven, Laura Dilissen, Ellen Marijsse, Gudrun Bullens, Dominique M

BACKGROUND: Daily intensive exercise by elite athletes can result in exercise-induced asthma especially in elite swimmers and this may be linked to epithelial damage. OBJECTIVE: To study airway epithelial damage and release of damage-associated molecular patterns (DAMPs) after intensive exercise in elite athletes and controls. METHODS: We recruited competitive swimmers (n = 26), competitive indoor athletes (n = 13) and controls (n = 15) without any history of asthma. Lung function was measured before, immediately after and 24 h after a 90-min intensive exercise protocol. Sputum induction was performed at baseline and 24 h after exercise. Exercise-induced bronchoconstriction (EIB) was assessed by the eucapnic voluntary hyperventilation test. RESULTS: Baseline sputum uric acid, high mobility group box-1, CXCL8 mRNA, sputum neutrophils and serum Clara cell protein-16 (CC-16) were significantly higher in competitive swimmers compared with controls. Intensive swimming for 90 min resulted in an increase of sputum IL-1β, IL-6 and TNF mRNA in competitive swimmers, and of sputum IL-6 mRNA and sputum neutrophils in controls. Although all participants were asymptomatic, seven competitive swimmers, one indoor athlete and one control met the criteria for EIB. CONCLUSION: Our findings show that the intensive training combined with exposure to by-products of chlorination induces airway epithelial damage in competitive swimmers. This is associated with increased damage-associated molecular patterns, innate cytokine release and neutrophilic airway inflammation.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès libre
Année de publication 2015
Langue Anglais
Information sur le périodique "Allergy" - Vol. 70, p. 187-194 (2015)
Peer reviewed oui
Editeur Wiley-Blackwell Publishing Ltd. ((Denmark) Copenhagen )
issn 0105-4538
e-issn 1398-9995
Statut de la publication Publié
Affiliations KUL - University Hospitals Leuven
Mots-clés Clara cell protein-16 ; elite athlete ; eucapnic voluntary hyperventilation ; exercise-induced bronchoconstriction ; uric acid
Liens
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Référence bibliographique Seys, Sven F ; Hox, Valérie ; Van Gerven, Laura ; Dilissen, Ellen ; Marijsse, Gudrun ; et. al. Damage-associated molecular pattern and innate cytokine release in the airways of competitive swimmers.. In: Allergy, Vol. 70, p. 187-194 (2015)
Permalien http://hdl.handle.net/2078/191193