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Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY

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Sautrey, Guillaume [UCL] El Khoury, Micheline [UCL] Giro Dos Santos, Andreia [UCL] Zimmermann, Louis Deleu, Magali Mingeot-Leclercq, Marie-Paule [UCL]

Bacterial membranes are highly organized, containing specific microdomains that facilitate distinct protein and lipid assemblies. Evidence suggests that cardiolipin molecules segregate into such microdomains, probably conferring a negative curvature to the inner plasma membrane during membrane fission upon cell division. 3',6-Dinonyl neamine is an amphiphilic aminoglycoside derivative active against Pseudomonas aeruginosa, including strains resistant to colistin. The mechanisms involved at the molecular level were identified using lipid models (large unilamellar vesicles, giant unilamelllar vesicles, and lipid monolayers) that mimic the inner membrane of P. aeruginosa The study demonstrated the interaction of 3',6-dinonyl neamine with cardiolipin and phosphatidylglycerol, two negatively charged lipids from inner bacterial membranes. This interaction induced membrane permeabilization and depolarization. Lateral segregation of cardiolipin and membrane hemifusion would be critical for explaining the effects induced on lipid membranes by amphiphilic aminoglycoside antibiotics. The findings contribute to an improved understanding of how amphiphilic aminoglycoside antibiotics that bind to negatively charged lipids like cardiolipin could be promising antibacterial compounds.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès libre
Année de publication 2016
Langue Anglais
Information sur le périodique "Journal of Biological Chemistry" - Vol. 291, no.26, p. 13864-13874 (2016)
Peer reviewed oui
Editeur American Society for Biochemistry and Molecular Biology, Inc. ((United States) Baltimore, MD)
issn 0021-9258
e-issn 1083-351X
Statut de la publication Publié
Affiliations UCL - SSS/LDRI - Louvain Drug Research Institute
Mots-clés Antibiotics ; Bacteria ; Cardiolipin ; Lipid bilayer ; Membrane lipid
Liens
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Référence bibliographique Sautrey, Guillaume ; El Khoury, Micheline ; Giro Dos Santos, Andreia ; Zimmermann, Louis ; Deleu, Magali ; et. al. Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY. In: Journal of Biological Chemistry, Vol. 291, no.26, p. 13864-13874 (2016)
Permalien http://hdl.handle.net/2078.1/175325