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Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.

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Garg, Abhishek D Galluzzi, Lorenzo Apetoh, Lionel Baert, Thais Birge, Raymond B Coulie, Pierre G. [UCL] Van den Eynde, Benoît [UCL] Agostinis, Patrizia [KU Leuven - University of Leuven]

The immunogenicity of malignant cells has recently been acknowledged as a critical determinant of efficacy in cancer therapy. Thus, besides developing direct immunostimulatory regimens, including dendritic cell-based vaccines, checkpoint-blocking therapies, and adoptive T-cell transfer, researchers have started to focus on the overall immunobiology of neoplastic cells. It is now clear that cancer cells can succumb to some anticancer therapies by undergoing a peculiar form of cell death that is characterized by an increased immunogenic potential, owing to the emission of the so-called "damage-associated molecular patterns" (DAMPs). The emission of DAMPs and other immunostimulatory factors by cells succumbing to immunogenic cell death (ICD) favors the establishment of a productive interface with the immune system. This results in the elicitation of tumor-targeting immune responses associated with the elimination of residual, treatment-resistant cancer cells, as well as with the establishment of immunological memory. Although ICD has been characterized with increased precision since its discovery, several questions remain to be addressed. Here, we summarize and tabulate the main molecular, immunological, preclinical, and clinical aspects of ICD, in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation.

Type de document Article de périodique (Journal article)
Type d'accès Accès libre
Année de publication 2015
Langue Anglais
Information sur le périodique "Frontiers in Immunology" - Vol. 6, p. 588 (2015)
Peer reviewed oui
Editeur Frontiers Research Foundation
issn 1664-3224
e-issn 1664-3224
Statut de la publication Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
Liens
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Référence bibliographique Garg, Abhishek D ; Galluzzi, Lorenzo ; Apetoh, Lionel ; Baert, Thais ; Birge, Raymond B ; et. al. Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death.. In: Frontiers in Immunology, Vol. 6, p. 588 (2015)
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