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microRNA-155, Induced by Interleukin-1ß, Represses the Expression of Microphthalmia-Associated Transcription Factor (MITF-M) in Melanoma Cells

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Arts, Nathalie [UCL] Cané, Stefania [UCL] Hennequart, Marc [UCL] Lamy, Juliette [UCL] Bommer, Guido [UCL] Van den Eynde, Benoît [UCL] De Plaen, Etienne [UCL]

Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein products can be recognized by cytolytic T lymphocytes. We previously reported that interleukin-1ß (IL-1ß) can downregulate MITF-M levels. Here we show that downregulation of MITF-M expression by IL-1ß was paralleled by an upregulation of miR-155 expression in four melanoma lines. We confirmed that miR-155 was able to target endogenous MITF-M in melanoma cells and demonstrated a role for miR-155 in the IL-1ß-induced repression of MITF-M by using an antagomiR. Notably, we also observed a strong negative correlation between MITF-M and miR-155 levels in a mouse model of melanoma. Taken together, our results indicate that MITF-M downregulation by inflammatory stimuli might be partly due to miR-155 upregulation. This could represent a novel mechanism of melanoma immune escape in an inflammatory microenvironment.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès libre
Année de publication 2015
Langue Anglais
Information sur le périodique "PLoS One" - Vol. 10, no.4, p. e0122517 (08/04/2015)
Peer reviewed oui
Editeur Public Library of Science
issn 1932-6203
e-issn 1932-6203
Statut de la publication Publié
Affiliations UCL - SSS/DDUV - Institut de Duve
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Référence bibliographique Arts, Nathalie ; Cané, Stefania ; Hennequart, Marc ; Lamy, Juliette ; Bommer, Guido ; et. al. microRNA-155, Induced by Interleukin-1ß, Represses the Expression of Microphthalmia-Associated Transcription Factor (MITF-M) in Melanoma Cells. In: PLoS One, Vol. 10, no.4, p. e0122517 (08/04/2015)
Permalien http://hdl.handle.net/2078.1/158669