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Antimicrobial silver: Uses, toxicity and potential for resistance

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Mijnendonckx, Kristel [UCL] Leys, Natalie [UCL] Mahillon, Jacques [UCL] Silver, Simon [University of Illinois, Chicago] Van Houdt, Rob [Belgian Nuclear Research Centre, Mol, Belgium]

This review gives a comprehensive overview of the widespread use and toxicity of silver compounds in many biological applications. Moreover, the bacterial silver resistance mechanisms and their spread in the environment are discussed. This study shows that it is important to understand in detail how silver and silver nanoparticles exert their toxicity and to understand how bacteria acquire silver resistance. Silver ions have shown to possess strong antimicrobial properties but cause no immediate and serious risk for human health, which led to an extensive use of silver-based products in many applications. However, the risk of silver nanoparticles is not yet clarified and their widespread use could increase silver release in the environment, which can have negative impacts on ecosystems. Moreover, it is shown that silver resistance determinants are widely spread among environmental and clinically relevant bacteria. These resistance determinants are often located on mobile genetic elements, facilitating their spread. Therefore, detailed knowledge of the silver toxicity and resistance mechanisms can improve its applications and lead to a better understanding of the impact on human health and ecosystems. © 2013 Springer Science+Business Media New York.

Type de document Article de périodique (Journal article) – Article de recherche
Type d'accès Accès restreint
Année de publication 2013
Langue Anglais
Information sur le périodique "BioMetals : an international journal on the role of metal ions in biology, biochemistry and medicine" - Vol. 26, no.4, p. 609-621 (2013)
Peer reviewed oui
Editeur Springer Netherlands ((Netherlands) Dordrecht)
issn 0966-0844
e-issn 1572-8773
Statut de la publication Publié
Affiliations UCL - SST/ELI/ELIM - Applied Microbiology
Mots-clés Resistance ; Silver ; Silver nanoparticles ; Toxicity ; 3131
Liens
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Référence bibliographique Mijnendonckx, Kristel ; Leys, Natalie ; Mahillon, Jacques ; Silver, Simon ; Van Houdt, Rob. Antimicrobial silver: Uses, toxicity and potential for resistance. In: BioMetals : an international journal on the role of metal ions in biology, biochemistry and medicine, Vol. 26, no.4, p. 609-621 (2013)
Permalien http://hdl.handle.net/2078.1/140703