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Displaying 14 results.
    • Journal article
    MPL Mutations in Essential Thrombocythemia Uncover A Common Path of Activation with Eltrombopag Dependent on W491.
    Levy, Gabriel[UCL] Carillo, Serge Papoular, Benjamin Cassinat, Bruno Zini, Jean Marc Leroy, Emilie[UCL] Varghese, Leila[UCL] Chachoua, Ilyas[UCL] Defour, Jean-Philippe[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] (2020) Blood — Vol. 135, no. 12, p. 948-953 (2020)
    • Journal article
    Orientation-specific signalling by thrombopoietin receptor dimers.
    Staerk, Judith Defour, Jean-Philippe[UCL] Pecquet, Christian[UCL] Leroy, Emilie[UCL] Poirel, Hélène[UCL] Brett, Ian Itaya, Miki Smith, Steven O Vainchenker, William Constantinescu, Stefan N.[UCL] (2011) The EMBO journal — Vol. 30, no.21, p. 4398-413 (2011)
    • Journal article
    Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer
    Seubert, Nadine[UCL] Royer, Yohan[UCL] Staerk, Judith[UCL] Kubatzky, Katharina F[UCL] Moucadel, Virginie[UCL] Krishnakumar, Shyam Smith, Steven O Constantinescu, Stefan N.[UCL] (2003) Molecular Cell — Vol. 12, no. 5, p. 1239-1250 (2003)
    • Journal article
    Presenilin Transmembrane Domain 8 conserved AxxxAxxxG Motifs Are Required for the Activity of the γ-Secretase Complex.
    Marinangeli, Claudia[UCL] Tasiaux, Bernadette[UCL] Opsomer, Rémi[UCL] Hage, Salim[UCL] Sodero, Alejandro[UCL] Dewachter, Ilse[UCL] Octave, Jean-Noël[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] Kienlen-Campard, Pascal[UCL] (2015) Journal of Biological Chemistry — Vol. 290, no. 11, p. 7169-7184 (2015)
    • Journal article
    His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.
    Leroy, Emilie[UCL] Defour, Jean-Philippe[UCL] Sato, Takeshi Dass, Sharmila Gryshkova, Vitalina[UCL] Shwe, Myat Marlar[UCL] Staerk, Judith Constantinescu, Stefan N.[UCL] Smith, Steven O (2015) Journal of Biological Chemistry — Vol. 291, no. 6, p. 1317-1324 (2015)
    • Journal article
    Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.
    Defour, Jean-Philippe Itaya, Miki Gryshkova, Vitalina Brett, Ian C Pecquet, Christian Sato, Takeshi Smith, Steven O Constantinescu, Stefan N.[UCL] (2013) Proceedings of the National academy of sciences of the United States of America — Vol. 110, no.7, p. 2540-5 (2013)
    • Journal article
    β-Sheet Structure within the Extracellular Domain of C99 Regulates Amyloidogenic Processing.
    Hu, Yi Kienlen-Campard, Pascal[UCL] Tang, Tzu-Chun Perrin, Florian[UCL] Opsomer, Rémi Decock, Marie Pan, Xiaoshu Octave, Jean-Noël[UCL] Constantinescu, Stefan N.[UCL#114651] Smith, Steven O (2017) Scientific Reports — Vol. 7, p. 17159 (2017)
    • Journal article
    Influence of the familial Alzheimer's disease-associated T43I mutation on the transmembrane structure and γ-secretase processing of the C99 peptide.
    Tang, Tzu-Chun Kienlen-Campard, Pascal[UCL] Hu, Yi Perrin, Florian Opsomer, Rémi[UCL] Octave, Jean-Noël[UCL] Constantinescu, Stefan N.[UCL] Smith, Steven O (2019) The Journal of biological chemistry — Vol. 294, no. 15, p. 5854-5866 (2019)
    • Journal article
    Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing.
    Decock, Marie[UCL] El Haylani, Laetitia[UCL] Stanga, Serena[UCL] Dewachter, Ilse[UCL] Octave, Jean-Noël[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] Kienlen-Campard, Pascal[UCL] (2015) F E B S Open Bio — Vol. 5, p. 763-773 (2015)
    • Journal article
    Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production.
    Tang, Tzu-Chun Hu, Yi Kienlen-Campard, Pascal[UCL] El Haylani, Laetitia[UCL] Decock, Marie[UCL] Van Hees, Joanne[UCL] Fu, Ziao Octave, Jean-Noël[UCL] Constantinescu, Stefan N.[UCL] Smith, Steven O (2014) Structure — Vol. 22, no. 3, p. 387-396 (2014)
    • Journal article
    Erratum : amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs
    Kienlen-Campard, Pascal[UCL] Tasiaux, Bernadette[UCL] Van Hees, Joanne[UCL] Li, Mingli[UCL] Huysseune, Sandra[UCL] Sato, Takeshi Fei, Jeffrey Z Aimoto, Saburo Smith, Steven O Constantinescu, Stefan N.[UCL] Octave, Jean-Noël[UCL] (2008) Journal of Biological Chemistry — Vol. 283, no. 12, p. 7733-7744 (2008)
    • Journal article
    Constitutive activation and oncogenicity are mediated by loss of helical structure at the cytosolic boundary of thrombopoietin receptor mutant dimers.
    Defour, Jean-Philippe[UCL] Leroy, Emilie[UCL] Dass, Sharmila Balligand, Thomas[UCL] Levy, Gabriel[UCL] Brett, Ian C Papadopoulos, Nicolas[UCL] Mouton, Céline[UCL] Genet, Lidvine[UCL] Pecquet, Christian[UCL] Stärk, Judith[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] (2023) eLife — Vol. 12, p. e81521 [1-26] (2023)
    • Journal article
    The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.
    Defour, Jean-Philippe[UCL] Levy, Gabriel[UCL] Leroy, Emilie[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] (2019) Leukemia — Vol. 33, no.2, p. 563-564 (2019)
    • Journal article
    Dimeric Transmembrane Orientations of APP/C99 Regulate γ-Secretase Processing Line Impacting Signaling and Oligomerization.
    Perrin, Florian Papadopoulos, Nicolas[UCL] Suelves Caballol, Nuria[UCL] Opsomer, Rémi Vadukul, Devkee M Vrancx, Céline Smith, Steven O Vertommen, Didier Kienlen-Campard, Pascal[UCL] Constantinescu, Stefan N.[UCL] (2020) iScience — Vol. 23, no.12, p. 101887 (2020)