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A review of the general aspects of radiofrequency ablation

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Ni, Yicheng [UCL] Mulier, Stefaan [MONT] Miao, Y Michel, Luc [UCL] Marchal, Gilberte [UCL]

As an alternative to standard surgical resection for the treatment of malignant tumors, radiofrequency ablation (RFA) has rapidly evolved into the most popular minimally invasive therapy. To help readers gain the relevant background knowledge and to better understand the other reviews in this Feature Section on the clinical applications of RFA in different abdominal organs, the present report covers the general aspects of RFA. After an introduction, we present a simple definition of the energy applied during RFA, a brief historical review of its technical evolution, and an explanation of the mechanism of action of RFA. These basic discussions are substantiated with descriptions of RFA equipment including those commercially available and those under preclinical development. The size and geometry of induced lesions in relation to RFA efficacy and side effects are discussed. The unique pathophysiologic process of thermal tissue damage and the corresponding histomorphologic manifestations after RFA are detailed and cross-referenced with the findings in the current literature. The crucial role of imaging technology during and after RFA is also addressed, including some promising new developments. This report finishes with a summary of the key messages and a perspective on further technologic refinements and identifies some specific priorities.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Abdominal Imaging" - Vol. 30, no. 4, p. 381-400 (2005)
Peer reviewed yes
Publisher Springer (New York)
issn 0942-8925
e-issn 1432-0509
Publication status Publié
Affiliation UCL - DRT/DPRI - Département de droit privé
Keywords radiofrequency ; tumor ablation ; minimally invasive therapy ; review
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Bibliographic reference Ni, Yicheng ; Mulier, Stefaan ; Miao, Y ; Michel, Luc ; Marchal, Gilberte. A review of the general aspects of radiofrequency ablation. In: Abdominal Imaging, Vol. 30, no. 4, p. 381-400 (2005)
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