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The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro.

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Godfraind, Theophile [UCL] Eglème, C Finet, M. Jaumin, P.

We have studied the action of nifedipine and nisoldipine on the contractile activity of human isolated coronary arteries and human isolated auricular and ventricular muscles. Nisoldipine depressed dose dependently the spontaneous rhythmic contractions displayed by the coronary artery preparations and at 1 nM abolished these contractions. Nisoldipine was twenty times more potent than nifedipine as an inhibitor of increase in tone induced by depolarization (100 mM K+). The rhythmic activity induced by serotonin (10 microM) was about five times more sensitive to nisoldipine than to nifedipine. In both auricular and ventricular preparations, isoprenaline evoked an increase in the rate of force development and in the rate of relaxation. Nifedipine was five times (ventricular muscles) and ten times (auricular muscles) more potent than nisoldipine as a negative inotropic agent. The present observations in human isolated preparations indicate that nisoldipine shows a higher vascular selectivity than nifedipine.

Document type Article de périodique (Journal article) – Comparative Study, In Vitro, Journal Article, Research Support, Non-U.S. Gov't
Publication date 1987
Journal information "Pharmacology & toxicology" - Vol. 61, no. 2, p. 79-84 (1987)
issn 0901-9928
Publication status Publié
Affiliation UCL
MESH Subject Adolescent ; Adult ; Aged ; Child ; Coronary Vessels - drug effects ; Humans ; Isoproterenol - pharmacology ; Middle Aged ; Myocardial Contraction - drug effects ; Nifedipine - analogs & derivatives - pharmacology ; Nisoldipine ; Serotonin Antagonists ; Vasoconstriction - drug effects ; Vasodilator Agents - pharmacology
Links
  1. Bean, Proc. Natl. Acad. Sci. U.S.A., 81, 6388 (1984)
  2. Braunwald, Amer. J. Cardiol., 27, 416 (1971)
  3. Finet M., Godfraind T., Khoury G., The positive inotropic action of the nifedipine analogue, Bay K 8644, in guinea-pig and rat isolated cardiac preparations, 10.1111/j.1476-5381.1985.tb09431.x
  4. Ginsburg, Eur. J. Pharmacol., 125, 287 (1986)
  5. Godfraind, Pharmacol. Rev., 38, 321 (1986)
  6. Godfraind, J. Pharmacol. Exp. Therap., 230, 514 (1984)
  7. Godfraind, Factors influencing the course of myocardial ischemia, 100 (1983)
  8. Godfraind T., Miller R.C., Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro, 10.1111/j.1476-5381.1983.tb10544.x
  9. Kalsner, Science, 223, 1435 (1984)
  10. Kazda, Arzneimittelforsch./Drug Res., 30, 2144 (1980)
  11. Maseri, Factors influencing the course of myocardial ischemia, 229 (1983)
  12. Oliva P. B., Breckinridge J. C., Arteriographic evidence of coronary arterial spasm in acute myocardial infarction, 10.1161/01.cir.56.3.366
  13. Scholz Hasso, Inotropic drugs and their mechanisms of action, 10.1016/s0735-1097(84)80231-4
  14. Voorde, Eur. J. Pharmacol., 87, 113 (1983)
  15. van Nueten Jan M., Vasodilatation or Inhibition of Peripheral Vasoconstriction?, Mechanisms of Vasodilatation ISBN:9783805528412 p.137-143, 10.1159/000401678
Bibliographic reference Godfraind, Theophile ; Eglème, C ; Finet, M. ; Jaumin, P.. The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro.. In: Pharmacology & toxicology, Vol. 61, no. 2, p. 79-84 (1987)
Permanent URL http://hdl.handle.net/2078.1/21813