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The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro.

Onglets principaux

Godfraind, Theophile [UCL] Eglème, C Finet, M. Jaumin, P.

We have studied the action of nifedipine and nisoldipine on the contractile activity of human isolated coronary arteries and human isolated auricular and ventricular muscles. Nisoldipine depressed dose dependently the spontaneous rhythmic contractions displayed by the coronary artery preparations and at 1 nM abolished these contractions. Nisoldipine was twenty times more potent than nifedipine as an inhibitor of increase in tone induced by depolarization (100 mM K+). The rhythmic activity induced by serotonin (10 microM) was about five times more sensitive to nisoldipine than to nifedipine. In both auricular and ventricular preparations, isoprenaline evoked an increase in the rate of force development and in the rate of relaxation. Nifedipine was five times (ventricular muscles) and ten times (auricular muscles) more potent than nisoldipine as a negative inotropic agent. The present observations in human isolated preparations indicate that nisoldipine shows a higher vascular selectivity than nifedipine.

Type de document Article de périodique (Journal article) – Comparative Study, In Vitro, Journal Article, Research Support, Non-U.S. Gov't
Année de publication 1987
Information sur le périodique "Pharmacology & toxicology" - Vol. 61, no. 2, p. 79-84 (1987)
issn 0901-9928
Statut de la publication Publié
Affiliations UCL
MESH Subject Adolescent ; Adult ; Aged ; Child ; Coronary Vessels - drug effects ; Humans ; Isoproterenol - pharmacology ; Middle Aged ; Myocardial Contraction - drug effects ; Nifedipine - analogs & derivatives - pharmacology ; Nisoldipine ; Serotonin Antagonists ; Vasoconstriction - drug effects ; Vasodilator Agents - pharmacology
Liens
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Référence bibliographique Godfraind, Theophile ; Eglème, C ; Finet, M. ; Jaumin, P.. The actions of nifedipine and nisoldipine on the contractile activity of human coronary arteries and human cardiac tissue in vitro.. In: Pharmacology & toxicology, Vol. 61, no. 2, p. 79-84 (1987)
Permalien http://hdl.handle.net/2078.1/21813