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Central nervous system regeneration is driven by microglia necroptosis and repopulation.

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Lloyd, Amy F Davies, Claire L Holloway, Rebecca K Labrak, Yasmine [UCL] Ireland, Graeme des Rieux, Anne [UCL] Miron, Veronique E

Failed regeneration of CNS myelin contributes to clinical decline in neuroinflammatory and neurodegenerative diseases, for which there is an unmet therapeutic need. Here we reveal that efficient remyelination requires death of proinflammatory microglia followed by repopulation to a pro-regenerative state. We propose that impaired microglia death and/or repopulation may underpin dysregulated microglia activation in neurological diseases, and we reveal therapeutic targets to promote white matter regeneration.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "Nature neuroscience" - Vol. 22, p. 1046-1052 (2019)
Peer reviewed yes
e-issn 1546-1726
Publication status Publié
Affiliation UCL - SSS/LDRI - Louvain Drug Research Institute
Links
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Bibliographic reference Lloyd, Amy F ; Davies, Claire L ; Holloway, Rebecca K ; Labrak, Yasmine ; Ireland, Graeme ; et. al. Central nervous system regeneration is driven by microglia necroptosis and repopulation.. In: Nature neuroscience, Vol. 22, p. 1046-1052 (2019)
Permanent URL http://hdl.handle.net/2078.1/217066