User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

A model of the mammalian optic nerve fibre based on experimental data.

Primary tabs

Oozeer, Medhi [UCL] Veraart, Claude [UCL] Legat, Vincent [UCL] Delbeke, Jean [UCL]

Several experimental data about membrane dynamics and pharmacological sensitivities of optic nerve axons have been published. The present work summarizes these data and computer simulations have been used to develop a model of the mammalian optic nerve fibre. The ionic currents description were derived from existing membrane models and particularly from a model of the somatic retinal ganglion cell (RGC) impulse generation. However, original equations had to be modified to match experimental data, which suggests that in RGCs, axonal and somatic ion channel expression are different. The new model is consistent with recent experimental results about optic nerve axonal excitability.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2006
Journal information "Vision research" - Vol. 46, no. 16, p. 2513-2524 (2006)
Peer reviewed yes
issn 0042-6989
Publication status Publié
Affiliations UCL - MD/FSIO - Département de physiologie et pharmacologie
UCL - FSA/MECA - Département de mécanique
MESH Subject 4-Aminopyridine - pharmacology ; Action Potentials - drug effects - physiology ; Animals ; Computer Simulation ; Models, Neurological ; Nerve Fibers, Myelinated - drug effects - physiology ; Optic Nerve - drug effects - physiology ; Potassium Channel Blockers - pharmacology ; Potassium Channels - physiology ; Rats ; Sodium Channels - physiology
Keywords Optic nerve ; Channels ; Prosthesis ; Mathematical model
Links
Bibliographic reference Oozeer, Medhi ; Veraart, Claude ; Legat, Vincent ; Delbeke, Jean. A model of the mammalian optic nerve fibre based on experimental data.. In: Vision research, Vol. 46, no. 16, p. 2513-2524 (2006)
Permanent URL http://hdl.handle.net/2078.1/10518