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Journal article

Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development

Balligand, Thomas[UCL] Achouri, Younes[UCL] Pecquet, Christian[UCL] Gaudray, Gilles[UCL] Colau, Didier[UCL] Hug, Eva Rahmani, Yacine[UCL] Stroobant, Vincent[UCL] Plo, Isabelle Vainchenker, William Kralovics, Robert Van Den Eynde, Benoît[UCL] Defour, Jean-Philippe[UCL] Constantinescu, Stefan N.[UCL] (2020) Leukemia — Vol. 34, no. 2, p. 510-521 (2020)

Journal article

The S505A thrombopoietin receptor mutation in childhood hereditary thrombocytosis and essential thrombocythemia is S505N: single letter amino acid code matters.

Defour, Jean-Philippe[UCL] Levy, Gabriel[UCL] Leroy, Emilie[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] (2019) Leukemia — Vol. 33, no.2, p. 563-564 (2019)

Journal article

MPL Mutations in Essential Thrombocythemia Uncover A Common Path of Activation with Eltrombopag Dependent on W491.

Levy, Gabriel[UCL] Carillo, Serge Papoular, Benjamin Cassinat, Bruno Zini, Jean Marc Leroy, Emilie[UCL] Varghese, Leila[UCL] Chachoua, Ilyas[UCL] Defour, Jean-Philippe[UCL] Smith, Steven O Constantinescu, Stefan N.[UCL] (2020) Blood — Vol. 135, no. 12, p. 948-953 (2020)

Journal article

Calreticulin mutants as oncogenic rogue chaperones for TpoR and traffic-defective pathogenic TpoR mutants

Pecquet, Christian[UCL] Chachoua, Ilyas Roy, Anita[UCL] Balligand, Thomas[UCL] Vertenoeil, Gaëlle[UCL] Leroy, Emilie Albu, Roxana-Irina Defour, Jean-Philippe[UCL] Nivarthi, Harini Hug, Eva Xu, Erica Ould Amer, Yasmine[UCL] Mouton, Céline[UCL] Colau, Didier[UCL] Vertommen, Didier[UCL] Shwe, Myat Marlar Marty, Caroline Plo, Isabelle Vainchenker, William Kralovics, Robert Constantinescu, Stefan N.[UCL] (2019) Blood — Vol. 133, no. 25, p. 2669-2681 (2019)

Journal article

Cooccurring V617F and R1063H mutations increase JAK2 signaling and neutrophilia in myeloproliferative neoplasms.

Mambet, Cristina[UCL] Babosova, Olga Defour, Jean-Philippe[UCL] Leroy, Emilie[UCL] Necula, Laura Stanca, Oana Tatic, Aurelia Berbec, Nicoleta Coriu, Daniel Belickova, Monika Kralova, Barbora Lanikova, Lucie Vesela, Jitka Pecquet, Christian[UCL] Saussoy, Pascale[UCL] Havelange, Violaine[UCL] Diaconu, Carmen C Divoky, Vladimir Constantinescu, Stefan N.[UCL] (2018) Blood — Vol. 132, no. 25, p. 2695-2699 (2018)

Journal article

Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms

Pecquet, Christian[UCL] Papadopoulos, Nicolas[UCL] Balligand, Thomas Chachoua, Ilyas Tisserand, Amandine Vertenoeil, Gaëlle[UCL] Nedelec, Audrey[UCL] Vertommen, Didier[UCL] Roy, Anita[UCL] Marty, Caroline Nivarthi, Harini Defour, Jean-Philippe[UCL] El-Khoury, Mira Hug, Eva Xu, Erica Zagrijtschuk, Oleh Fertig, Emmanuel Marta, Daciana Gisslinger, Heinz Gisslinger, Bettina Schalling, Martin Casetti, Ilaria Rumi, Elisa Pietra, Daniela Cavalloni, Chiara Arcaini, Luca Cazzola, Mario Komatsu, Norio Kihara, Yoshihiko Sunami, Yoshitaka Edahiro, Yoko Araki, Marito Lesyk, Roman Buxhofer-Ausch, Veronika Heibl, Sonja Pasquier, Florence Havelange, Violaine[UCL] Plo, Isabelle Vainchenker, William Kralovics, Robert Constantinescu, Stefan N.[UCL] (2023) Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms — Vol. 141, no. 8, p. 917-929 (2023)

Journal article

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution.

Cabagnols, X Defour, Jean-Philippe[UCL] Ugo, V Ianotto, J C Mossuz, P Mondet, J Girodon, F Alexandre, J H Mansier, O Viallard, J F Lippert, E Murati, A Mozziconacci, M J Saussoy, Pascale[UCL] Vekemans, Marie-Christiane[UCL] Knoops, Laurent[UCL] Pasquier, F Ribrag, V Solary, E Plo, I Constantinescu, Stefan N.[UCL] Casadevall, N Vainchenker, W Marzac, C Bluteau, O (2015) Leukemia — Vol. 29, no.1, p. 249-52 (2015)

Journal article

INNOVATIONS 2018 EN ONCO-HÉMATOLOGIE

Havelange, Violaine[UCL] Poire, Xavier[UCL] Defour, Jean-Philippe[UCL] Constantinescu, Stefan N.[UCL] Saussoy, Pascale[UCL] Van Den Neste, Eric[UCL] Bailly Sarah[UCL] (2019) Louvain médical — Vol. 138, no.2, p. 112-118 (2019)

Journal article

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes.

Pecquet, Christian[UCL] Diaconu, Carmen C Staerk, Judith Girardot, Michael Marty, Caroline Royer, Yohan Defour, Jean-Philippe[UCL] Dusa, Alexandra Besancenot, Rodolphe Giraudier, Stephane Villeval, Jean-Luc Knoops, Laurent Courtoy, Pierre J.[UCL] Vainchenker, William Constantinescu, Stefan N.[UCL] (2012) Blood — Vol. 119, no. 20, p. 4625-4635 (2012)

Journal article

An unusual, activating insertion/deletion MPL mutant in primary myelofibrosis.

Defour, Jean-Philippe[UCL] Hoade, Yvette Reuther, A-M Callaway, Alison Ward, Daniel Chen, Frederick Constantinescu, Stefan N.[UCL] Cross, Nicholas C.P. (2017) Leukemia — Vol. 31, no. 8, p. 1838-1839 (2017)

Speech

Crispr/Cas9 Engineered 61bp Deletion in the Calr Gene of Mice Leads to Development of Thrombocytosis

Balligand, Thomas[UCL] Achouri, Younes[UCL] Chachoua, Ilyas[UCL] Pecquet, Christian[UCL] Defour, Jean-Philippe[UCL] Constantinescu, Stefan N.[UCL] (2016) 58th meeting of the American Society of Hematology — San Diego

Journal article

Combination treatment for myeloproliferative neoplasms using JAK and pan-class I PI3K inhibitors.

Choong, Meng Ling Pecquet, Christian[UCL] Pendharkar, Vishal Diaconu, Carmen C Yong, Jacklyn Wei Yan Tai, Shi Jing Wang, Si Fang Defour, Jean-Philippe[UCL] Sangthongpitag, Kanda Villeval, Jean-Luc Vainchenker, William Constantinescu, Stefan N.[UCL] Lee, May Ann (2013) Journal of Cellular and Molecular Medicine (Print) : a journal of translational medicine — Vol. 17, no.11, p. 1397-1409 (2013)

Journal article

His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor.

Leroy, Emilie[UCL] Defour, Jean-Philippe[UCL] Sato, Takeshi Dass, Sharmila Gryshkova, Vitalina[UCL] Shwe, Myat Marlar[UCL] Staerk, Judith Constantinescu, Stefan N.[UCL] Smith, Steven O (2015) Journal of Biological Chemistry — Vol. 291, no. 6, p. 1317-1324 (2015)

Journal article

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

Chachoua, Ilyas[UCL] Pecquet, Christian[UCL] El-Khoury, Mira Nivarthi, Harini Albu, Roxana-Irina Marty, Caroline Gryshkova, Vitalina Defour, Jean-Philippe Vertenoeil, Gaëlle Ngo, Anna Koay, Ann Raslova, Hana Courtoy, Pierre J.[UCL] Choong, Meng Ling Plo, Isabelle Vainchenker, William Kralovics, Robert Constantinescu, Stefan N.[UCL] (2016) Blood — Vol. 127, no. 10, p. 1325-35 (2016)

Journal article

Orientation-specific signalling by thrombopoietin receptor dimers.

Staerk, Judith Defour, Jean-Philippe[UCL] Pecquet, Christian[UCL] Leroy, Emilie[UCL] Poirel, Hélène[UCL] Brett, Ian Itaya, Miki Smith, Steven O Vainchenker, William Constantinescu, Stefan N.[UCL] (2011) The EMBO journal — Vol. 30, no.21, p. 4398-413 (2011)

Journal article

Presence of atypical thrombopoietin receptor (MPL) mutations in triple negative essential thrombocythemia patients.

Cabagnols, Xénia Favale, Fabrizia Pasquier, Florence Messaoudi, Kahia Defour, Jean-Philippe[UCL] Ianotto, Jean Christophe Marzac, Christophe Le Couédic, Jean Pierre Droin, Nathalie Chachoua, Ilyas[UCL] Favier, Remi Diop, M'boyba Khadija Ugo, Valérie Casadevall, Nicole Debili, Najet Raslova, Hana Bellanne-Chantelot, Christine Constantinescu, Stefan N.[UCL] Bluteau, Olivier Plo, Isabelle Vainchenker, William (2016) Blood — Vol. 127, no. 3, p. 333-342 (2016)

Journal article

Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.

Defour, Jean-Philippe Itaya, Miki Gryshkova, Vitalina Brett, Ian C Pecquet, Christian Sato, Takeshi Smith, Steven O Constantinescu, Stefan N.[UCL] (2013) Proceedings of the National academy of sciences of the United States of America — Vol. 110, no.7, p. 2540-5 (2013)

Journal article

Oncogenic activation of MPL/thrombopoietin receptor by 17 mutations at W515: implications for myeloproliferative neoplasms.

Defour, Jean-Philippe[UCL] Chachoua, Ilyas[UCL] Pecquet, Christian[UCL] Constantinescu, Stefan N.[UCL] (2015) Leukemia — Vol. 30, no. 5, p. 1214-1216 (2015)

Journal article

The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.

Varghese, Leila[UCL] Defour, Jean-Philippe[UCL] Pecquet, Christian Constantinescu, Stefan N.[UCL] (2017) Frontiers in Endocrinology — Vol. 8, p. 59 [1-13] (2017)

Journal article

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

Favale, Fabrizia Messaoudi, Kahia Varghese, Leila[UCL] Boukour, Siham Pecquet, Christian[UCL] Gryshkova, Vitalina[UCL] Defour, Jean-Philippe[UCL] Albu, Roxana-Irina Bluteau, Olivier Ballerini, Paola Leverger, Guy Plo, Isabelle Debili, Najet Raslova, Hana Favier, Remi Constantinescu, Stefan N.[UCL] Vainchenker, William (2016) Blood — Vol. 128, no. 26, p. 3146-3158 (2016)

Journal article

A biological profile for diagnosis and outcome of COVID-19 patients.

Khourssaji, Mehdi[UCL] Chapelle, Virginie[UCL] Evenepoel, Anton[UCL] Belkhir, Leïla[UCL] Yombi, Jean Cyr[UCL] van Dievoet, Marie-Astrid[UCL] Saussoy, Pascale[UCL] Coche, Emmanuel[UCL] Fillee, Catherine[UCL] Constantinescu, Stefan N.[UCL] Rodriguez-Villalobos, Hector[UCL] Defour, Jean-Philippe[UCL] Gruson, Damien[UCL] (2020) Clinical chemistry and laboratory medicine — Vol. 58, no. 12, p. 2141-2150 (2020)

Journal article

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution.

Cabagnols, X Defour, Jean-Philippe[UCL] Ugo, V Ianotto, J C Mossuz, P Mondet, J Girodon, F Alexandre, J H Mansier, O Viallard, J F Lippert, E Murati, A Mozziconacci, M J Saussoy, P Vekemans, Marie-Christiane[UCL] Knoops, Laurent[UCL] Pasquier, F Ribrag, V Solary, E Plo, I Constantinescu, Stefan N.[UCL] Casadevall, N Vainchenker, W Marzac, C Bluteau, O (2015) Leukemia — Vol. 29, no. 1, p. 249-252 (2014)

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