User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Potentially Inappropriate Prescribing and Related Hospital Admissions in Geriatric Patients: A Comparative Analysis between the STOPP and START Criteria Versions 1 and 2

Primary tabs

download
  • Open access
  • PDF
  • 399.00 K
Thevelin, Stefanie [UCL] El Mounaouar, Leïla [UCL] Marien, Sophie [UCL] Boland, Benoît [UCL] Henrard, Séverine [UCL] Dalleur, Olivia [UCL]

(eng) BACKGROUND: Older persons are at significant risk of drug-related admissions (DRAs). We previously demonstrated that 27% of hospitalizations in geriatric patients were associated with potentially inappropriate medicines (PIMs) and/or potential prescribing omissions (PPOs) identified by the Screening Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment (STOPP/START) criteria version 1 (v1). The updated STOPP/START criteria version 2 (v2) comprised a 31% increase in prescribing criteria. OBJECTIVE: As a secondary analysis of our study conducted in 2008, we aimed to compare the prevalence and types of DRAs identified by STOPP/START.v1 and STOPP/START.v2. METHODS: We applied the STOPP/START.v2 criteria to a subset of 100 consecutively admitted geriatric patients selected from our original cross-sectional study of 302 patients. A geriatrician and a pharmacist adjudicated whether the identified PIMs and PPOs were related to acute hospitalization. Admissions were defined as DRAs if the identified PIM(s) and/or PPO(s) were related to the main cause of admission or played a significant contributory role in the admission. RESULTS: The median patient age was 83 years and the median number of medications at home was 8. Compared with STOPP/START.v1, STOPP/START.v2 not only yielded more instances of inappropriate prescribing but also targeted significantly more PIMs and PPOs associated with preventable DRAs (23% vs. 40% of all admissions, p < 0.001). PIMs of fall-risk-increasing drugs, and PPOs of musculoskeletal and cardiovascular system drugs, were most frequently associated with DRAs. CONCLUSION: The latter instances of inappropriate prescribing with major clinical relevance warrant particular attention during medication review in older persons.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès libre
Publication date 2019
Language Anglais
Journal information "Drugs & aging" - Vol. 36, no. 5, p. 453-459 (2019)
Peer reviewed yes
Publisher Springer International ((New Zealand) Auckland)
issn 1170-229X
e-issn 1179-1969
Publication status Publié
Affiliations UCL - SSS/IRSS - Institut de recherche santé et société
UCL - SSS/LDRI - Louvain Drug Research Institute
UCL - (SLuc) Département de pharmacie
UCL - (SLuc) Service de gériatrie
Keywords Pharmacology (medical) ; Geriatrics and Gerontology
Links
  1. Parameswaran Nair Nibu, Chalmers Leanne, M Peterson Gregory, Bereznicki Bonnie, L Castelino Ronald, Bereznicki Luke, Hospitalization in older patients due to adverse drug reactions – the need for a prediction tool, 10.2147/cia.s99097
  2. El Morabet Najla, Uitvlugt Elien B., van den Bemt Bart J.F., van den Bemt Patricia M.L.A., Janssen Marjo J.A., Karapinar-Çarkit Fatma, Prevalence and Preventability of Drug-Related Hospital Readmissions: A Systematic Review, 10.1111/jgs.15244
  3. Ernst Frank R., Grizzle Amy J., Drug-Related Morbidity and Mortality: Updating the Cost-of-Illness Model, 10.1016/s1086-5802(16)31229-3
  4. Leendertse Anne J., Van Den Bemt Patricia M.L.A., Poolman J. Bart, Stoker Lennart J., Egberts Antoine C.G., Postma Maarten J., Preventable hospital admissions related to medication (HARM): Cost analysis of the HARM study, 10.1016/j.jval.2010.10.024
  5. Leendertse AJ, Egberts AC, Stoker LJ, van den Bemt PM. Frequency of and risk factors for preventable medication-related hospital admissions in the Netherlands. Arch Intern Med. 2008;168(17):1890–6.
  6. Budnitz Daniel S., Lovegrove Maribeth C., Shehab Nadine, Richards Chesley L., Emergency Hospitalizations for Adverse Drug Events in Older Americans, 10.1056/nejmsa1103053
  7. Runciman W. B., Adverse drug events and medication errors in Australia, 10.1093/intqhc/mzg085
  8. Franceschi Marilisa, Scarcelli Carlo, Niro Valeria, Seripa Davide, Pazienza Anna Maria, Pepe Giovanni, Colusso Anna Maria, Pacilli Luigi, Pilotto Alberto, Prevalence, Clinical Features and Avoidability of Adverse Drug Reactions as Cause of Admission to??a??Geriatric Unit : A Prospective Study of 1756 Patients, 10.2165/00002018-200831060-00009
  9. Dalleur Olivia, Spinewine Anne, Henrard Séverine, Losseau Claire, Speybroeck Niko, Boland Benoit, Inappropriate Prescribing and Related Hospital Admissions in Frail Older Persons According to the STOPP and START Criteria, 10.1007/s40266-012-0016-1
  10. Hamilton Hilary, Gallagher Paul, Ryan Cristin, Byrne Stephen, O’Mahony Denis, Potentially Inappropriate Medications Defined by STOPP Criteria and the Risk of Adverse Drug Events in Older Hospitalized Patients, 10.1001/archinternmed.2011.215
  11. van der Stelt CA, Vermeulen Windsant-van den Tweel AM, Egberts AC, van den Bemt PM, Leendertse AJ, Hermens WA, et al. The association between potentially inappropriate prescribing and medication-related hospital admissions in older patients: a nested case control study. Drug Saf. 2016;39(1):79–87.
  12. Gallagher P., O'Mahony D., STOPP (Screening Tool of Older Persons' potentially inappropriate Prescriptions): application to acutely ill elderly patients and comparison with Beers' criteria, 10.1093/ageing/afn197
  13. Spinewine Anne, Schmader Kenneth E, Barber Nick, Hughes Carmel, Lapane Kate L, Swine Christian, Hanlon Joseph T, Appropriate prescribing in elderly people: how well can it be measured and optimised?, 10.1016/s0140-6736(07)61091-5
  14. Gallagher P, Ryan C, Byrne S, Kennedy J, O’Mahony D. STOPP (Screening Tool of Older Person’s Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation. Int J Clin Pharmacol Ther. 2008;46(2):72–83.
  15. O'Mahony Denis, O'Sullivan David, Byrne Stephen, O'Connor Marie Noelle, Ryan Cristin, Gallagher Paul, STOPP/START criteria for potentially inappropriate prescribing in older people: version 2, 10.1093/ageing/afu145
  16. Boland B., Guignard B., Dalleur O., Lang P.-O., Application of STOPP/START and Beers criteria: Compared analysis on identification and relevance of potentially inappropriate prescriptions, 10.1016/j.eurger.2016.03.010
  17. Blanco-Reina Encarnación, García-Merino Maria Rosa, Ocaña-Riola Ricardo, Aguilar-Cano Lorena, Valdellós Jennifer, Bellido-Estévez Inmaculada, Ariza-Zafra Gabriel, Assessing Potentially Inappropriate Prescribing in Community-Dwelling Older Patients Using the Updated Version of STOPP-START Criteria: A Comparison of Profiles and Prevalences with Respect to the Original Version, 10.1371/journal.pone.0167586
  18. McCusker J, Bellavance F, Cardin S, Belzile E, Verdon J. Prediction of hospital utilization among elderly patients during the 6 months after an emergency department visit. Ann Emerg Med. 2000;36(5):438–45.
  19. Deschodt Mieke, Braes Tom, Broos Paul, Sermon An, Boonen Steven, Flamaing Johan, Milisen Koen, Effect of an Inpatient Geriatric Consultation Team on Functional Outcome, Mortality, Institutionalization, and Readmission Rate in Older Adults with Hip Fracture: A Controlled Trial : EFFECT OF AN INPATIENT GERIATRIC CONSULTATION, 10.1111/j.1532-5415.2011.03488.x
  20. HALLAS J., HARVALD B., GRAM L. F., GRODUM E., BRØSEN K., HAGHFELT T., DAMSBO N., Drug related hospital admissions: the role of definitions and intensity of data collection, and the possibility of prevention, 10.1111/j.1365-2796.1990.tb00199.x
  21. Viera AJ, Garrett JM. Understanding interobserver agreement: the kappa statistic. Fam Med. 2005;37(5):360–3.
  22. Counter David, Millar James W. T., McLay James S., Hospital readmissions, mortality and potentially inappropriate prescribing: a retrospective study of older adults discharged from hospital : Potentially inappropriate prescriptions, 10.1111/bcp.13607
  23. Wauters Maarten, Elseviers Monique, Vaes Bert, Degryse Jan, Dalleur Olivia, Vander Stichele Robert, Christiaens Thierry, Azermai Majda, Too many, too few, or too unsafe? Impact of inappropriate prescribing on mortality, and hospitalization in a cohort of community-dwelling oldest old : Too many, too few, or too unsafe?, 10.1111/bcp.13055
  24. Lang PO, Petrovic M, Dalleur O, Ferahta M, Benetos A, Boland B. The exercise in applying STOPP/START.v2 in vulnerable very old patients: Towards patient tailored prescribing. Eur Geriatr Med. 2016;7(2):176–9.
  25. Holmes Holly M., Hayley Déon Cox, Alexander G. Caleb, Sachs Greg A., Reconsidering Medication Appropriateness for Patients Late in Life, 10.1001/archinte.166.6.605
  26. Fischhoff B. Hindsight not equal to foresight: the effect of outcome knowledge on judgment under uncertainty. 1975. Qual Saf Health Care. 2003;12(4):304–11 (discussion 11–2).
  27. Thevelin Stefanie, Spinewine Anne, Beuscart Jean-Baptiste, Boland Benoit, Marien Sophie, Vaillant Fanny, Wilting Ingeborg, Vondeling Ariel, Floriani Carmen, Schneider Claudio, Donzé Jacques, Rodondi Nicolas, Cullinan Shane, O'Mahony Denis, Dalleur Olivia, Development of a standardized chart review method to identify drug-related hospital admissions in older people : A standardized chart review method to identify DRA in older people, 10.1111/bcp.13716
  28. Phansalkar Shobha, Hoffman Jennifer M., Nebeker Jonathan R., Hurdle John F., Pharmacists versus nonpharmacists in adverse drug event detection: A meta-analysis and systematic review, 10.2146/ajhp060335
  29. van Doormaal Jasperien E., Mol Peter G. M., van den Bemt Patricia M. L. A., Zaal Rianne J., Egberts Antoine C. G., Kosterink Jos G. W., Haaijer‐Ruskamp Flora M., Reliability of the assessment of preventable adverse drug events in daily clinical practice, 10.1002/pds.1586
Bibliographic reference Thevelin, Stefanie ; El Mounaouar, Leïla ; Marien, Sophie ; Boland, Benoît ; Henrard, Séverine ; et. al. Potentially Inappropriate Prescribing and Related Hospital Admissions in Geriatric Patients: A Comparative Analysis between the STOPP and START Criteria Versions 1 and 2. In: Drugs & aging, Vol. 36, no. 5, p. 453-459 (2019)
Permanent URL http://hdl.handle.net/2078.1/214119