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EAACI Position paper on the standardization of nasal allergen challenges.

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Auge, Julia [Department for Medical Statistics, Informatics and 10 Epidemiology, IMSIE, Medical Faculty of the University of Cologne] Vent, julia [Department for Medical Statistics, Informatics and 10 Epidemiology, IMSIE, Medical Faculty of the University of Cologne] Agache, Ioana [Transylvania University Brasov] Airaksinen, Liisa [Finnish Institute of Occupational Health] Campo, Paloma [IBIMA-Regional University Hospital of Málaga] Hox, Valérie [UCL] Mösges, Ralph [Department for Medical Statistics, Informatics and 10 Epidemiology, IMSIE, Medical Faculty of the University of Cologne]

Nasal allergen challenge (NAC) is an important tool to diagnose allergic rhinitis. In daily clinical routine, experimentally, or when measuring therapeutic success clinically, nasal allergen challenge is fundamental. It is further one of the key diagnostic tools when initiating specific allergen immunotherapy. So far, national recommendations offered guidance on its execution; however, international divergence left many questions unanswered. These differences in the literature caused EAACI to initiate a task force to answer unmet needs and find a consensus in executing nasal allergen challenge. On the basis of a systematic review containing nasal allergen challenges of the past years, task force members reviewed evidence, discussed open issues, and studied variations of several subjective and objective assessment parameters to propose a standardized way of a nasal allergen challenge procedure in clinical practice. Besides an update on indications, contraindications, and preparations for the test procedure, main recommendations are a bilaterally challenge with standardized allergens, with a spray device offering 0.1 mL per nostril. A systematic catalogue for positivity criteria is given for the variety of established subjective and objective assessment methods as well as a schedule for the challenge procedure. The task force recommends a unified protocol for NAC for daily clinical practice, aiming at eliminating the previous difficulty of comparing NAC results due to unmet needs.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès interdit
Publication date 2018
Language Anglais
Journal information "EAACI Position paper on the standardization of nasal allergen challenges" - Vol. 73, no.8, p. 1597 (2018)
Peer reviewed yes
Publisher Cezmi Akdis
issn 1398-9995
e-issn 1398-9995
Publication status Publié
Affiliation Cliniques Universitaires Saint-Luc - Department of Otorhinolaryngology
Links
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Bibliographic reference Auge, Julia ; Vent, julia ; Agache, Ioana ; Airaksinen, Liisa ; Campo, Paloma ; et. al. EAACI Position paper on the standardization of nasal allergen challenges.. In: EAACI Position paper on the standardization of nasal allergen challenges, Vol. 73, no.8, p. 1597 (2018)
Permanent URL http://hdl.handle.net/2078/213256