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Fostering responsible research with genome editing technologies: a European perspective

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Botbol-Baum, Mylene [UCL]

In this consensus paper resulting from a meeting that involved representatives from more than 20 European partners, we recommend the foundation of an expert group (European Steering Committee) to assess the potential benefits and draw-backs of genome editing (off-targets, mosaicisms, etc.), and to design risk matrices and scenarios for a responsible use of this promising technology. In addition, this European steering committee will contribute in promoting an open debate on societal aspects prior to a translation into national and international legislation.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "Transgenic Research" - (2017)
Peer reviewed yes
Publisher Springer Netherlands ((Netherlands) Dordrecht)
issn 0962-8819
e-issn 1573-9368
Publication status Publié
Affiliations UCL - SSS/IRSS - Institut de recherche santé et société
UCL - SSH/ISP - Institut supérieur de philosophie
Links
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  4. Gaj Thomas, Gersbach Charles A., Barbas Carlos F., ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering, 10.1016/j.tibtech.2013.04.004
  5. Gantz V. M., Bier E., The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations, 10.1126/science.aaa5945
  6. Mojica Francisco J.M., Montoliu Lluis, On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals, 10.1016/j.tim.2016.06.005
  7. Rauch Benjamin J., Silvis Melanie R., Hultquist Judd F., Waters Christopher S., McGregor Michael J., Krogan Nevan J., Bondy-Denomy Joseph, Inhibition of CRISPR-Cas9 with Bacteriophage Proteins, 10.1016/j.cell.2016.12.009
  8. Zetsche Bernd, Gootenberg Jonathan S., Abudayyeh Omar O., Slaymaker Ian M., Makarova Kira S., Essletzbichler Patrick, Volz Sara E., Joung Julia, van der Oost John, Regev Aviv, Koonin Eugene V., Zhang Feng, Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System, 10.1016/j.cell.2015.09.038
Bibliographic reference Botbol-Baum, Mylene. Fostering responsible research with genome editing technologies: a European perspective. In: Transgenic Research, (2017)
Permanent URL http://hdl.handle.net/2078.1/187071