User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Predictive factors associated with biochemical recurrence following radical prostatectomy for pathological T2 prostate cancer with negative surgical margins.

Primary tabs

Aoun, Fouad Albisinni, Simone Henriet, Benjamin Tombal, Bertrand [UCL] Van Velthoven, Roland Roumeguère, Thierry

(eng) OBJECTIVE: The aim of this study was to determine factors associated with the development of biochemical recurrence (BCR) following radical prostatectomy in patients with pathological T2 prostate cancer and negative surgical margins. MATERIALS AND METHODS: This retrospective multicentre cohort study included 1252 consecutive patients with pT2 pN0/Nx and negative surgical margins on radical prostatectomy and without any adjuvant treatment, performed in three Belgian centres. BCR-free survival curves were estimated using the Kaplan-Meier method. Univariate and multivariate analyses using the Cox proportional hazards model were performed to determine clinical and pathological predictive factors of BCR in this group of patients. RESULTS: In total, 910 patients were included. BCR occurred in 107 patients (11.8%) at a median follow-up of 108 months. Overall 5 and 10 year BCR-free survival rates were 90% and 87%, respectively. On the multivariate analyses, serum prostate-specific antigen (PSA) level (p = .001) and surgical Gleason score of 7 or above (p = .001) were significantly associated with BCR in men with pathological T2 prostate cancer with negative surgical margins. Perineural invasion and capsular infiltration were not risk factors for recurrence. CONCLUSIONS: This study identified unfavourable risk factors in patients with pathological T2 and negative surgical margins following radical prostatectomy. The results suggest that patients with a surgical Gleason score of 7 or higher, unknown lymph-node status and high PSA values are at increased risk of recurrence.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2017
Language Anglais
Journal information "Scandinavian Journal of Urology" - Vol. 51, no. 1, p. 20-26 (2017)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 2168-1805
e-issn 2168-1813
Publication status Publié
Affiliations UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation
UCL - (SLuc) Service d'urologie
Keywords Biochemical recurrence ; Gleason score ; PSA ; negative surgical margin ; radical prostatectomy
Links
  1. Fitzmaurice Christina, Dicker Daniel, Pain Amanda, Hamavid Hannah, Moradi-Lakeh Maziar, MacIntyre Michael F., Allen Christine, Hansen Gillian, Woodbrook Rachel, Wolfe Charles, Hamadeh Randah R., Moore Ami, Werdecker Andrea, Gessner Bradford D., Te Ao Braden, McMahon Brian, Karimkhani Chante, Yu Chuanhua, Cooke Graham S., Schwebel David C., Carpenter David O., Pereira David M., Nash Denis, Kazi Dhruv S., De Leo Diego, Plass Dietrich, Ukwaja Kingsley N., Thurston George D., Yun Jin Kim, Simard Edgar P., Mills Edward, Park Eun-Kee, Catalá-López Ferrán, deVeber Gabrielle, Gotay Carolyn, Khan Gulfaraz, Hosgood H. Dean, Santos Itamar S., Leasher Janet L., Singh Jasvinder, Leigh James, Jonas Jost B., Sanabria Juan, Beardsley Justin, Jacobsen Kathryn H., Takahashi Ken, Franklin Richard C., Ronfani Luca, Montico Marcella, Naldi Luigi, Tonelli Marcello, Geleijnse Johanna, Petzold Max, Shrime Mark G, Younis Mustafa, Yonemoto Naohiro, Breitborde Nicholas, Yip Paul, Pourmalek Farshad, Lotufo Paulo A., Esteghamati Alireza, Hankey Graeme J., Ali Raghib, Lunevicius Raimundas, Malekzadeh Reza, Dellavalle Robert, Weintraub Robert, Lucas Robyn, Hay Roderick, Rojas-Rueda David, Westerman Ronny, Sepanlou Sadaf G., Nolte Sandra, Patten Scott, Weichenthal Scott, Abera Semaw Ferede, Fereshtehnejad Seyed-Mohammad, Shiue Ivy, Driscoll Tim, Vasankari Tommi, Alsharif Ubai, Rahimi-Movaghar Vafa, Vlassov Vasiliy V., Marcenes W. S., Mekonnen Wubegzier, Melaku Yohannes Adama, Yano Yuichiro, Artaman Al, Campos Ismael, MacLachlan Jennifer, Mueller Ulrich, Kim Daniel, Trillini Matias, Eshrati Babak, Williams Hywel C., Shibuya Kenji, Dandona Rakhi, Murthy Kinnari, Cowie Benjamin, Amare Azmeraw T., Antonio Carl Abelardo, Castañeda-Orjuela Carlos, van Gool Coen H., Violante Francesco, Oh In-Hwan, Deribe Kedede, Soreide Kjetil, Knibbs Luke, Kereselidze Maia, Green Mark, Cardenas Rosario, Roy Nobhojit, Tillmann Taavi, Li Yongmei, Krueger Hans, Monasta Lorenzo, Dey Subhojit, Sheikhbahaei Sara, Hafezi-Nejad Nima, Kumar G. Anil, Sreeramareddy Chandrashekhar T., Dandona Lalit, Wang Haidong, Vollset Stein Emil, Mokdad Ali, Salomon Joshua A., Lozano Rafael, Vos Theo, Forouzanfar Mohammad, Lopez Alan, Murray Christopher, Naghavi Mohsen, The Global Burden of Cancer 2013, 10.1001/jamaoncol.2015.0735
  2. Heidenreich Axel, Bastian Patrick J., Bellmunt Joaquim, Bolla Michel, Joniau Steven, van der Kwast Theodor, Mason Malcolm, Matveev Vsevolod, Wiegel Thomas, Zattoni Filiberto, Mottet Nicolas, EAU Guidelines on Prostate Cancer. Part II: Treatment of Advanced, Relapsing, and Castration-Resistant Prostate Cancer, 10.1016/j.eururo.2013.11.002
  3. Bill-Axelson Anna, Holmberg Lars, Garmo Hans, Rider Jennifer R., Taari Kimmo, Busch Christer, Nordling Stig, Häggman Michael, Andersson Swen-Olof, Spångberg Anders, Andrén Ove, Palmgren Juni, Steineck Gunnar, Adami Hans-Olov, Johansson Jan-Erik, Radical Prostatectomy or Watchful Waiting in Early Prostate Cancer, 10.1056/nejmoa1311593
  4. Wilt Timothy J., Brawer Michael K., Jones Karen M., Barry Michael J., Aronson William J., Fox Steven, Gingrich Jeffrey R., Wei John T., Gilhooly Patricia, Grob B. Mayer, Nsouli Imad, Iyer Padmini, Cartagena Ruben, Snider Glenn, Roehrborn Claus, Sharifi Roohollah, Blank William, Pandya Parikshit, Andriole Gerald L., Culkin Daniel, Wheeler Thomas, Radical Prostatectomy versus Observation for Localized Prostate Cancer, 10.1056/nejmoa1113162
  5. Mottet N, Bellmunt J, Briers E, van den Bergh RCH, Bolla M, van Casteren NJ, et al. Guidelines on prostate cancer. European Association of Urology; 2015. Available from http://uroweb.org/wp-content/uploads/EAU-Guidelines-Prostate-Cancer-2015-v2.pdf
  6. Budäus Lars, Isbarn Hendrik, Eichelberg Christian, Lughezzani Giovanni, Sun Maxine, Perrotte Paul, Chun Felix K.H., Salomon Georg, Steuber Thomas, Köllermann Jens, Sauter Guido, Ahyai Sascha A., Zacharias Mario, Fisch Margit, Schlomm Thorsten, Haese Alexander, Heinzer Hans, Huland Hartwig, Montorsi Francesco, Graefen Markus, Karakiewicz Pierre I., Biochemical Recurrence After Radical Prostatectomy: Multiplicative Interaction Between Surgical Margin Status and Pathological Stage, 10.1016/j.juro.2010.06.018
  7. Ravery V, Prog Urol, 5, 968 (1995)
  8. Cookson Michael S., Aus Gunnar, Burnett Arthur L., Canby-Hagino Edith D., D’Amico Anthony V., Dmochowski Roger R., Eton David T., Forman Jeffrey D., Goldenberg S. Larry, Hernandez Javier, Higano Celestia S., Kraus Stephen R., Moul Judd W., Tangen Catherine, Thrasher J. Brantley, Thompson Ian, Variation in the Definition of Biochemical Recurrence in Patients Treated for Localized Prostate Cancer: The American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel Report and Recommendations for a Standard in the Reporting of Surgical Outcomes, 10.1016/j.juro.2006.10.097
  9. Tanimoto Ryuta, Fashola Yomi, Scotland Kymora B, Calvaresi Anne E, Gomella Leonard G, Trabulsi Edouard J, Lallas Costas D, Risk factors for biochemical recurrence after robotic assisted radical prostatectomy: a single surgeon experience, 10.1186/s12894-015-0024-7
  10. Ploussard Guillaume, Agamy Mohammad Ali, Alenda Olivier, Allory Yves, Mouracade Pascal, Vordos Dimitri, Hoznek Andras, Abbou Claude-Clément, de la Taille Alexandre, Salomon Laurent, Impact of positive surgical margins on prostate-specific antigen failure after radical prostatectomy in adjuvant treatment-naïve patients : PSA FAILURE AFTER RADICAL PROSTATECTOMY, 10.1111/j.1464-410x.2010.09728.x
  11. Fine Samson W., Amin Mahul B., Berney Daniel M., Bjartell Anders, Egevad Lars, Epstein Jonathan I., Humphrey Peter A., Magi-Galluzzi Christina, Montironi Rodolfo, Stief Christian, A Contemporary Update on Pathology Reporting for Prostate Cancer: Biopsy and Radical Prostatectomy Specimens, 10.1016/j.eururo.2012.02.055
  12. Samaratunga Hemamali, Montironi Rodolfo, True Lawrence, Epstein Jonathan I, Griffiths David F, Humphrey Peter A, van der Kwast Theo, Wheeler Thomas M, Srigley John R, Delahunt Brett, Egevad Lars, International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 1: specimen handling, 10.1038/modpathol.2010.178
  13. Egevad Lars, Handling of radical prostatectomy specimens : Handling of prostatectomies, 10.1111/j.1365-2559.2011.04002.x
  14. Hall G. Scott, Kramer Charles E., Epstein Jonathan I., Evaluation of Radical Prostatectomy Specimens : A Comparative Analysis of Sampling Methods, 10.1097/00000478-199204000-00001
  15. Evans Andrew J., Henry Pauline C., Van der Kwast Theodorus H., Tkachuk Douglas C., Watson Kemp, Lockwood Gina A., Fleshner Neil E., Cheung Carol, Belanger Eric C., Amin Mahul B., Boccon-Gibod Liliane, Bostwick David G., Egevad Lars, Epstein Jonathan I., Grignon David J., Jones Edward C., Montironi Rodolfo, Moussa Madeleine, Sweet Joan M., Trpkov Kiril, Wheeler Thomas M., Srigley John R., Interobserver Variability Between Expert Urologic Pathologists for Extraprostatic Extension and Surgical Margin Status in Radical Prostatectomy Specimens : , 10.1097/pas.0b013e31817fb3a0
  16. Lu Jian, Wirth Gregory J., Wu Shulin, Chen Junxing, Dahl Douglas M., Olumi Aria F., Young Robert H., McDougal W. Scott, Wu Chin-Lee, A Close Surgical Margin After Radical Prostatectomy is an Independent Predictor of Recurrence, 10.1016/j.juro.2012.02.2565
  17. Izard Jason P., True Lawrence D., May Philip, Ellis William J., Lange Paul H., Dalkin Bruce, Lin Daniel W., Schmidt Rodney A., Wright Jonathan L., Prostate Cancer That Is Within 0.1 mm of the Surgical Margin of a Radical Prostatectomy Predicts Greater Likelihood of Recurrence : , 10.1097/pas.0000000000000162
  18. Koulikov Dmitry, Mohler Maura C., Mehedint Diana C., Attwood Kristopher, Wilding Gregory E., Mohler James L., Low Detectable Prostate Specific Antigen after Radical Prostatectomy—Treat or Watch?, 10.1016/j.juro.2014.05.088
  19. Lecouvet Frédéric E., El Mouedden Jawad, Collette Laurence, Coche Emmanuel, Danse Etienne, Jamar François, Machiels Jean-Pascal, Vande Berg Bruno, Omoumi Patrick, Tombal Bertrand, Can Whole-body Magnetic Resonance Imaging with Diffusion-weighted Imaging Replace Tc 99m Bone Scanning and Computed Tomography for Single-step Detection of Metastases in Patients with High-risk Prostate Cancer?, 10.1016/j.eururo.2012.02.020
  20. Palisaar R.-Jüri, Graefen Markus, Karakiewicz Pierre I, Hammerer Peter G, Huland Edith, Haese Alexander, Fernandez Salvator, Erbersdobler Andreas, Henke Rolf-Peter, Huland Hartwig, Assessment of Clinical and Pathologic Characteristics Predisposing to Disease Recurrence Following Radical Prostatectomy in Men with Pathologically Organ-Confined Prostate Cancer, 10.1016/s0302-2838(01)00025-2
  21. Chun Felix K.H., Briganti Alberto, Graefen Markus, Erbersdobler Andreas, Walz Jochen, Schlomm Thorsten, Meschke Mirja, Haese Alexander, Valiquette Luc, Huland Hartwig, Karakiewicz Pierre I., Body mass index does not improve the ability to predict biochemical recurrence after radical prostatectomy, 10.1016/j.ejca.2006.08.037
  22. DeLancey John O., Wood David P., He Chang, Montgomery Jeffrey S., Weizer Alon Z., Miller David C., Jacobs Bruce L., Montie James E., Hollenbeck Brent K., Skolarus Ted A., Evidence of Perineural Invasion on Prostate Biopsy Specimen and Survival After Radical Prostatectomy, 10.1016/j.urology.2012.09.034
  23. Miyake H, Hinyokika Kiyo, 51, 241 (2005)
  24. Maru Norio, Ohori Makoto, Kattan Michael W., Scardino Peter T., Wheeler Thomas M., Prognostic significance of the diameter of perineural invasion in radical prostatectomy specimens, 10.1053/hupa.2001.26456
  25. Sooriakumaran Prasanna, Ploumidis Achilles, Nyberg Tommy, Olsson Mats, Akre Olof, Haendler Leif, Egevad Lars, Nilsson Andreas, Carlsson Stefan, Jonsson Martin, Adding Christofer, Hosseini Abolfazl, Steineck Gunnar, Wiklund Peter, The impact of length and location of positive margins in predicting biochemical recurrence after robot-assisted radical prostatectomy with a minimum follow-up of 5 years : Length and location of PSM and predicting biochemical recurrence after RARP, 10.1111/bju.12483
  26. Mitsuzuka K, Narita S, Koie T, Kaiho Y, Tsuchiya N, Yoneyama T, Kakoi N, Kawamura S, Tochigi T, Ohyama C, Habuchi T, Arai Y, Lymphovascular invasion is significantly associated with biochemical relapse after radical prostatectomy even in patients with pT2N0 negative resection margin, 10.1038/pcan.2014.40
  27. Savdie Richard, Horvath Lisa G., Benito Ruth Pe, Rasiah Krishan K., Haynes Anne-Maree, Chatfield Mark, Stricker Phillip D., Turner Jennifer J., Delprado Warwick, Henshall Susan M., Sutherland Robert L., Kench James G., High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy : PREDICTORS OF BIOCHEMICAL RECURRENCE IN PROSTATE CANCER, 10.1111/j.1464-410x.2011.10572.x
Bibliographic reference Aoun, Fouad ; Albisinni, Simone ; Henriet, Benjamin ; Tombal, Bertrand ; Van Velthoven, Roland ; et. al. Predictive factors associated with biochemical recurrence following radical prostatectomy for pathological T2 prostate cancer with negative surgical margins.. In: Scandinavian Journal of Urology, Vol. 51, no. 1, p. 20-26 (2017)
Permanent URL http://hdl.handle.net/2078.1/182384