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Cardiotoxicity of childhood cancer treatment: update and current knowledge on long-term follow-up.

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de Ville de Goyet, Maëlle [UCL] Moniotte, Stéphane [UCL] Brichard, Bénédicte [UCL]

Therapeutic advances in paediatric oncology allowed increasing numbers of children to survive until adulthood. However, chemotherapy and radiotherapy are potentially cardiotoxic and contribute to a significant morbidity and mortality, cardiovascular events remaining the leading cause of death among survivors. This review summarizes the physiopathology of treatment-related cardiovascular diseases, their incidence, and the risk factors associated with each specific therapy. Few studies have investigated the cardiac outcomes of adult surviving from childhood cancers but all demonstrated a substantial risk for late cardiac effects. Cardiovascular monitoring, prevention, and early detection of cardiac dysfunction are, therefore, the keystones of an improved long-term outcome.

Document type Article de périodique (Journal article) – Synthèse de littérature
Access type Accès restreint
Publication date 2012
Language Anglais
Journal information "Pediatric hematology and oncology" - Vol. 29, no. 5, p. 395-414 (2012)
Peer reviewed yes
Publisher Informa Healthcare ((United Kingdom) London)
issn 0888-0018
e-issn 1521-0669
Publication status Publié
Affiliations UCL - SSS/IREC/PEDI - Pôle de Pédiatrie
UCL - (SLuc) Service de cardiologie pédiatrique
UCL - (SLuc) Service d'hématologie et d'oncologie pédiatrique
MESH Subject Adolescent ; Monitoring, Physiologic ; Neoplasms ; Adult ; Cardiovascular Diseases ; Child ; Child, Preschool ; Follow-Up Studies ; Humans ; Infant ; Male
Keywords Cardiotoxicity ; chemotherapy
Links
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Bibliographic reference de Ville de Goyet, Maëlle ; Moniotte, Stéphane ; Brichard, Bénédicte. Cardiotoxicity of childhood cancer treatment: update and current knowledge on long-term follow-up.. In: Pediatric hematology and oncology, Vol. 29, no. 5, p. 395-414 (2012)
Permanent URL http://hdl.handle.net/2078/123891