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Cerebrovascular disorders: molecular insights and therapeutic opportunities.

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Storkebaum, Erik Quaegebeur, Annelies Vikkula, Miikka Carmeliet, Peter

Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological disorders. Here we will discuss molecular insights into neurological disorders resulting either from excessive vessel growth (cerebral vascular malformations) or improper vessel regression (neurodegeneration and white matter lesions). These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic.

Document type Article de périodique (Journal article)
Access type Accès restreint
Publication date 2011
Language Anglais
Journal information "Nature Neuroscience" - Vol. 14, no.11, p. 1390-7 (2011)
Peer reviewed yes
Publisher Nature Publishing Group ((United States) New York)
issn 1097-6256
e-issn 1546-1726
Affiliation UCL - SSS/DDUV - Institut de Duve
MESH Subject Animals ; Cerebrovascular Disorders ; Humans ; Models, Biological ; Mutation ; Receptors, Notch ; Signal Transduction
Links
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Bibliographic reference Storkebaum, Erik ; Quaegebeur, Annelies ; Vikkula, Miikka ; Carmeliet, Peter. Cerebrovascular disorders: molecular insights and therapeutic opportunities.. In: Nature Neuroscience, Vol. 14, no.11, p. 1390-7 (2011)
Permanent URL http://hdl.handle.net/2078.1/120171