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Diterpenes from the leaves of Croton zambesicus.

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Block, Sebastien Baccelli, Chiara Tinant, Bernard [UCL] Van Meervelt, Luc Rozenberg, Raoul [UCL] Habib Jiwan, Jean-Louis [UCL] Quetin-Leclercq, Joëlle [UCL]

Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2004
Journal information "Phytochemistry" - Vol. 65, no. 8, p. 1165-71 (2004)
Peer reviewed yes
issn 0031-9422
Publication status Publié
Affiliations UCL - SC/CHIM - Département de chimie
UCL - MD/FARM - Ecole de pharmacie
MESH Subject Antineoplastic Agents, Phytogenic - chemistry - isolation & purification - pharmacology ; Cell Line ; Croton - chemistry ; Crystallography, X-Ray ; Diterpenes - chemistry - isolation & purification - pharmacology ; Drug Screening Assays, Antitumor ; Fibroblasts ; HL-60 Cells ; Hela Cells ; Humans ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Plant Leaves - chemistry
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Bibliographic reference Block, Sebastien ; Baccelli, Chiara ; Tinant, Bernard ; Van Meervelt, Luc ; Rozenberg, Raoul ; et. al. Diterpenes from the leaves of Croton zambesicus.. In: Phytochemistry, Vol. 65, no. 8, p. 1165-71 (2004)
Permanent URL http://hdl.handle.net/2078.1/9820