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Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice.

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Arany, E [] Strutt, B [] Romanus, P [UCL] Remacle, C [UCL] Reusens, Brigitte [UCL] Hill, D J []

We hypothesised that nutritional taurine, which is important for the development of the endocrine pancreas and reduces cytokine-induced apoptosis in pancreatic beta cells, would prevent or delay the onset of autoimmune diabetes, if given early in life to the non-obese diabetic (NOD) mouse.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès libre
Publication date 2004
Language Anglais
Journal information "Diabetologia" - Vol. 47, no. 10, p. 1831-7 (2004)
Peer reviewed yes
issn 0012-186X
Publication status Publié
Affiliation UCL - SC/BIOL - Département de biologie
MESH Subject Animals ; Diabetes Mellitus, Type 1 - prevention & control ; Pregnancy ; Prenatal Exposure Delayed Effects ; Reference Values ; Taurine - pharmacology ; Dietary Supplements ; Female ; Insulin - metabolism ; Islets of Langerhans - cytology, drug effects ; Male ; Mice ; Mice, Inbred NOD ; Organ Size - drug effects
Links
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Bibliographic reference Arany, E ; Strutt, B ; Romanus, P ; Remacle, C ; Reusens, Brigitte ; et. al. Taurine supplement in early life altered islet morphology, decreased insulitis and delayed the onset of diabetes in non-obese diabetic mice.. In: Diabetologia, Vol. 47, no. 10, p. 1831-7 (2004)
Permanent URL http://hdl.handle.net/2078.1/92788