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Antiproliferative effect of octreotide in somatotroph pituitary adenomas: discussion from a single case report.

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Delgrange, Etienne [UCL] Trouillas, J Gustin, Thierry [MONT] Gilliard, Claude [UCL] Donckier, Julian [UCL]

The case of a 20-year-old man presenting with a rapidly expanding pituitary somatotrophic adenoma with a tumour volume doubling time of 426 days is reported. Preoperative octreotide therapy induced a 45% tumour shrinkage and proliferating cells were absent at the time of tumoural resection. The correlation between clinical and proliferation markers data in this single case report affords an opportunity to discuss the antitumoral effect of octreotide on somatotrophic adenomas which may result from a suppression of cell proliferation.

Document type Article de périodique (Journal article) – Case Reports, Journal Article
Access type Accès restreint
Publication date 2001
Journal information "Acta neurochirurgica" - Vol. 143, no. 7, p. 733-6 (2001)
Peer reviewed yes
issn 0001-6268
Publication status Publié
Affiliations UCL - (MGD) Service de neurochirurgie
UCL - (SLuc) Service de neurologie
UCL - MD/NOPS - Département de neurologie et de psychiatrie
UCL - MD/CHIR - Département de chirurgie
MESH Subject Adenoma - diagnosis - drug therapy - pathology ; Adult ; Antineoplastic Agents, Hormonal - therapeutic use ; Growth Hormone - antagonists & inhibitors ; Humans ; Male ; Neoplasm Recurrence, Local - drug therapy ; Octreotide - therapeutic use ; Pituitary Neoplasms - diagnosis - drug therapy - pathology - surgery ; Treatment Outcome
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Bibliographic reference Delgrange, Etienne ; Trouillas, J ; Gustin, Thierry ; Gilliard, Claude ; Donckier, Julian. Antiproliferative effect of octreotide in somatotroph pituitary adenomas: discussion from a single case report.. In: Acta neurochirurgica, Vol. 143, no. 7, p. 733-6 (2001)
Permanent URL http://hdl.handle.net/2078.1/8937