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Pharmacological treatment of delayed cerebral ischemia and vasospasm in subarachnoid hemorrhage.

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Castanares Zapatero, Diego [UCL] Hantson, Philippe [UCL]

ABSTRACT: Subarachnoid hemorrhage after the rupture of a cerebral aneurysm is the cause of 6% to 8% of all cerebrovascular accidents involving 10 of 100,000 people each year. Despite effective treatment of the aneurysm, delayed cerebral ischemia (DCI) is observed in 30% of patients, with a peak on the tenth day, resulting in significant infirmity and mortality. Cerebral vasospasm occurs in more than half of all patients and is recognized as the main cause of delayed cerebral ischemia after subarachnoid hemorrhage. Its treatment comprises hemodynamic management and endovascular procedures. To date, the only drug shown to be efficacious on both the incidence of vasospasm and poor outcome is nimodipine. Given its modest effects, new pharmacological treatments are being developed to prevent and treat DCI. We review the different drugs currently being tested.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès libre
Publication date 2011
Language Anglais
Journal information "Annals of Intensive Care" - Vol. 1, no. 1, p. 12 (2011)
Peer reviewed yes
Publisher Springer ([S.l.])
issn 2110-5820
e-issn 2110-5820
Publication status Publié
Affiliations UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology
UCL - (SLuc) Service de soins intensifs
UCL - (SLuc) Centre de toxicologie clinique
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Bibliographic reference Castanares Zapatero, Diego ; Hantson, Philippe. Pharmacological treatment of delayed cerebral ischemia and vasospasm in subarachnoid hemorrhage.. In: Annals of Intensive Care, Vol. 1, no. 1, p. 12 (2011)
Permanent URL http://hdl.handle.net/2078.1/88987