Cavalier, J F
Burton, M
Dussart, F
Marchand, Chantal
[UCL]
Rees, Jean-François
[UCL]
Marchand-Brynaert, Jacqueline
[UCL]
A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.
Bibliographic reference |
Cavalier, J F ; Burton, M ; Dussart, F ; Marchand, Chantal ; Rees, Jean-François ; et. al. Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.. In: Bioorganic & medicinal chemistry, Vol. 9, no. 4, p. 1037-44 (2001) |
Permanent URL |
http://hdl.handle.net/2078.1/8839 |