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Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.

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Cavalier, J F Burton, M Dussart, F Marchand, Chantal [UCL] Rees, Jean-François [UCL] Marchand-Brynaert, Jacqueline [UCL]

A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Access type Accès restreint
Publication date 2001
Journal information "Bioorganic & medicinal chemistry" - Vol. 9, no. 4, p. 1037-44 (2001)
Peer reviewed yes
issn 0968-0896
Publication status Publié
Affiliation UCL - SC/BIOL - Département de biologie
MESH Subject Antioxidants - chemical synthesis - pharmacology ; Catechols - chemical synthesis - pharmacology ; Cell Line ; Culture Media ; Humans ; L-Lactate Dehydrogenase - metabolism ; NAD - metabolism ; Pyrazines - chemical synthesis - pharmacology ; Radiation-Protective Agents - chemical synthesis - pharmacology ; Ultraviolet Rays
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Bibliographic reference Cavalier, J F ; Burton, M ; Dussart, F ; Marchand, Chantal ; Rees, Jean-François ; et. al. Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.. In: Bioorganic & medicinal chemistry, Vol. 9, no. 4, p. 1037-44 (2001)
Permanent URL http://hdl.handle.net/2078.1/8839