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Synthesis, Structure and Reactions of Seco-steroids Containing a Medium-sized Ring .26. Structure Determination of Isoxazolidine Derivatives Obtained From (e)-unsaturated 5,10-seco-steroidal Ketones
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Synthesis, Structure and Reactions of Seco-steroids Containing a Medium-sized Ring .26. Structure Determination of Isoxazolidine Derivatives Obtained From (e)-unsaturated 5,10-seco-steroidal Ketones
(E)-Δ*1(10) -unsaturated 5-oxo-5,10-seco-steroids such as 1, react with hydroxylamine and N-methylhydroxylamine to give stereospecifically isoxazolidine derivatives of type 2 and 3, respectively. The molecular structure of isoxazolidine 3a obtained from (E)-3β-acetoxy-5,10-seco-cholest-1 (10)-en-5-one (la) and N-methylhydroxylamine has been determined by X-ray analysis.
Lorenc Ljubinka, Rajković Milica, Milovanović Aleksandar, Mihailović Mihailo Lj., Structure–reactivity relationships in normal and 19-nor-5,10-seco-steroidal cyclodecenone systems. Part 1. Acid-catalyzed and thermal reactions, 10.1039/p19880001495
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Bibliographic reference
Tinant, Bernard ; Declercq, Jean-Paul ; Van-Meerssche, M. ; Mihailovic, ML. ; Lorenc, L. ; et. al. Synthesis, Structure and Reactions of Seco-steroids Containing a Medium-sized Ring .26. Structure Determination of Isoxazolidine Derivatives Obtained From (e)-unsaturated 5,10-seco-steroidal Ketones. In: Societes Chimiques Belges. Bulletin, Vol. 97, no. 7, p. 485-491 (1988)