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Sequential Induction Chemotherapy With Vincristine, Daunorubicin, Cyclophosphamide, and Prednisone in Adult Acute Lymphoblastic-leukemia

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Thomas, X. Danaila, C. Bach, QK. Dufour, Philippe [UCL] Christian, B. Bosly, André [UCL] Fiere, D.

Sequential chemotherapy with vincristine, daunorubicin, cyclophosphamide, and prednisone doses was administered to 57 adult patients with acute lymphoblastic leukemia (ALL). Complete remission (CR) was achieved in 51 (89%, 95% confidence intervals, [CI] 78-96%). Among patients achieving CR, 62% were in CR after one sequence of chemotherapy, 23% after two sequences, and 5% after three sequences. Six patients (11%) had resistant disease. All patients experienced profound myelosuppression. Median time to recovery of neutrophils >0.5 x 10(9)/l was 22 days (range: 5-89 days), and of platelets >100 x 10(9)/l 21 days (range: 0-45 days). Nonhematologic WHO grade 3 or more side effects consisted predominantly of hyperbilirubinemia (7%), mucositis (5%), nausea and vomiting (2%), and cutaneous toxicity (1%). Severe infectious complications occurred in only 14% of cases. One patient (2%, 95% CI 0-9%) died of therapy-related toxicity while in early CR. We concluded that sequential use of prednisone seemed at least as effective as continuous administration at the expense of a few adverse side effects.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1995
Language Anglais
Journal information "Annals of Hematology" - Vol. 70, no. 2, p. 65-69 (1995)
Peer reviewed yes
Publisher Springer Verlag (New York)
issn 0939-5555
e-issn 1432-0584
Publication status Publié
Affiliation UCL - MD/MINT - Département de médecine interne
Keywords ACUTE LYMPHOBLASTIC LEUKEMIA ; LEUKEMIA ; CHEMOTHERAPY ; PREDNISONE
Links
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Bibliographic reference Thomas, X. ; Danaila, C. ; Bach, QK. ; Dufour, Philippe ; Christian, B. ; et. al. Sequential Induction Chemotherapy With Vincristine, Daunorubicin, Cyclophosphamide, and Prednisone in Adult Acute Lymphoblastic-leukemia. In: Annals of Hematology, Vol. 70, no. 2, p. 65-69 (1995)
Permanent URL http://hdl.handle.net/2078.1/48521