User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Physiological inhibition of growth hormone secretion by both insulin-like growth factors-I and -II in chickens

Primary tabs

Spencer, GSG Buyse, J. Decuypere, E. Rahimi, G

1. The role of both insulin-like growth factors (IGF)-I and -II in regulation of growth hormone GH) secretion in chickens was examined. Seven-week-old male broiler chickens were injected intravenously (iv) with recombinant human IGF-I or IGF-II or specific anti-IGF-I or IGF-II immunoglobulins. Blood samples were taken before treatment and at 15 min intervals afterwards for 1 h. Controls received saline iv. 2. Both IGF-I and IGF-II administration resulted in a rapid, significant decrease in plasma GH concentrations, but the concentrations of both triiodothyronine and thyroxine remained unchanged. 3. Immunisation against both IGF-I and IGF-II produced a significant elevation in plasma GH. 4. These data show that both IGFs can regulate GH concentrations in birds. Furthermore, the immunoneutralisation data suggest that these hormones have a physiological role in the regulation of GH secretion.

Document type Article de périodique (Journal article) – Article de recherche
Publication date 1997
Language Anglais
Journal information "British Poultry Science" - Vol. 38, no. 4, p. 429-431 (1997)
Peer reviewed yes
Publisher Carfax Publ Co (Abingdon)
issn 0007-1668
e-issn 1466-1799
Publication status Publié
Affiliation UCL
Links
  1. Belchetz Paul E., Ridley Rosalind M., Baker Harry F., Studies on the accessibility of prolactin and growth hormone to brain: effect of opiate agonists on hormone levels in serial, simultaneous plasma and cerebrospinal fluid samples in the rhesus monkey, 10.1016/0006-8993(82)90858-7
  2. Berghman Luc R., Lens P., Decuypere E., Kühn E.R., Vandesande F., Glycosylated chicken growth hormone, 10.1016/0016-6480(87)90079-7
  3. Buonomo F.C., Lauterio T.J., Baile C.A., Daughaday W.H., Effects of insulin-like growth factor I (IGF-I) on growth hormone-releasing factor (GRF) and thyrotropin-releasing hormone (TRH) stimulation of growth hormone (GH) secretion in the domestic fowl (Gallus domesticus), 10.1016/0016-6480(87)90277-2
  4. Canfield W.M., Journal of Biological Chemistry, 264, 7100 (1989)
  5. Clairmont K.B., Journal of Biological Chemistry, 264, 16390 (1989)
  6. DECUYPERE E., BUYSE J., SCANES C. G., HUYBRECHTS L., KÜHN E. R., Effects of hyper- or hypothyroid status on growth, adiposity and levels of growth hormone, somatomedin C and thyroid metabolism in broiler chickens, 10.1051/rnd:19870414
  7. Decuypere E., Leenstra FR, Buyse J., Huybrechts LM, Buonomo FC, Berghman LR, Plasma levels of growth hormone and insulin-like growth factor-I and -II from 2 to 6 weeks of age in meat-type chickens selected for 6-week body weight or for feed conversion and reared under high or normal environmental temperature conditions, 10.1051/rnd:19930405
  8. Duclos M. J., Goddard C., Insulin-like growth factor receptors in chicken liver membranes: binding properties, specificity, developmental pattern and evidence for a single receptor type, 10.1677/joe.0.1250199
  9. Harel Z., Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion, 10.1210/en.131.2.758
  10. Harvey S., Endocrinology of Birds: Molecular to Behavioural, 111 (1990)
  11. Harvey S., Baidwan J. S., Feedback-inhibition of growth hormone (GH) secretion in fowl: GH-induced down-regulation of thyrotrophin-releasing hormone binding to pituitary membranes, 10.1677/jme.0.0040013
  12. Harvey S., Baidwan J. S., Attardo D., Homologous and heterologous regulation of somatostatin-binding sites on chicken adenohypophysial membranes, 10.1677/joe.0.1270417
  13. Huybrechts L.M., Poultry Science, 71, 181 (1992)
  14. Huybrechts L. M., King D. B., Lauterio T. J., Marsh J., Scanes C. G., Plasma concentrations of somatomedin-C in hypophysectomized, dwarf and intact growing domestic fowl as determined by heterologous radioimmunoassay, 10.1677/joe.0.1040233
  15. Lea R. W., Harvey S., Feedback effects of growth hormone on anterior pituitary function in chickens, 10.1677/joe.0.1250409
  16. Lea R. W., Ahene C. A., Marsh J. A., Harvey S., Short-loop inhibition of thyrotrophin-releasing hormone-induced growth hormone secretion in fowl, 10.1677/joe.0.1260237
  17. McGuinness M.C., Cogburn L.A., Response of young broiler chickens to chronic injection of recombinant-derived human insulin-like growth factor-I, 10.1016/0739-7240(91)90031-e
  18. Spencer, G.S.G., Hodgkinson, S.C. and Bass, J.J. Central effects of insulin‐like growth factors on GH secretion. Second International Symposium on Insulin‐like Growth Factors/ Somatomedins. San Francisco. pp.201
  19. SPENCER G. S. G., HODGKINSON S. C., BASS J. J., Passive Immunization against Insulin-Like Growth Factor-I Does not Inhibit Growth Hormone- Stimulated Growth of Dwarf Rats, 10.1210/endo-128-4-2103
  20. Spencer G.S.G., Berry C., Hodgkinson S.C., Bass J.J., On the Neuroendocrine Role of Insulin-like Growth Factors 1 and 2 in the Regulation of Growth Hormone Secretion, 10.1006/mcne.1993.1066
  21. Spencer G.S.G., Comparative Biochemistry and Physiology, 110, 29 (1995)
  22. Spencer G.S.G., Poultry Science, 75, 388 (1996)
  23. Forster Malcolm E, The Blood Sinus System of Hagfish: Its Significance in a Low-pressure Circulation, 10.1016/s0300-9629(96)00215-0
Bibliographic reference Spencer, GSG ; Buyse, J. ; Decuypere, E. ; Rahimi, G. Physiological inhibition of growth hormone secretion by both insulin-like growth factors-I and -II in chickens. In: British Poultry Science, Vol. 38, no. 4, p. 429-431 (1997)
Permanent URL http://hdl.handle.net/2078.1/45992