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A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells

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Vigneron, Nathalie [UCL] Ooms, Annie [ULg] Morel, Sandra [UCL] Ma, Wenbin [UCL] Degiovanni, Gérard [ULg] Van den Eynde, Benoît [UCL]

A panel of autologous cytolytic T lymphocyte (CTL) clones have been isolated from blood lymphocytes of a melanoma patient after in vitro stimulation with autologous tumor cells. We previously reported the molecular definition of three distinct antigens recognized by some of these CTL clones. We describe here, the identification of a fourth antigenic peptide expressed by this melanoma line and recognized by a CTL clone restricted by HLA-B*3503. The antigenic peptide, which is nine-amino acid long, has the sequence LPHSSSHWL and is derived from melanocyte differentiation antigen gp100. As HLA-B35 is one of the most frequent HLA-B alleles, being present in 20% of the Caucasian individuals, this peptide may be a good target for peptide-based immunotherapy of melanoma.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Tissue Antigens" - Vol. 65, no. 2, p. 156-162 (2005)
Peer reviewed yes
Publisher Wiley-Blackwell Munksgaard ((Denmark) Copenhagen V)
issn 0001-2815
e-issn 1399-0039
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject gp100 Melanoma Antigen ; Tumor Cells, Cultured ; T-Lymphocytes, Cytotoxic - immunology ; Skin Neoplasms - genetics - immunology ; Peptide Fragments - chemistry - immunology ; Neoplasm Proteins - immunology ; Molecular Sequence Data ; Membrane Glycoproteins - immunology ; Melanoma - genetics - immunology ; Melanocytes - immunology - metabolism ; Humans ; HLA-B35 Antigen - genetics - immunology ; Cytotoxicity, Immunologic ; Cercopithecus aethiops ; COS Cells ; Animals ; Amino Acid Sequence
Keywords CTL ; gp100 ; HLA-B35 ; melanoma ; peptide
Links
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Bibliographic reference Vigneron, Nathalie ; Ooms, Annie ; Morel, Sandra ; Ma, Wenbin ; Degiovanni, Gérard ; et. al. A peptide derived from melanocytic protein gp100 and presented by HLA-B35 is recognized by autologous cytolytic T lymphocytes on melanoma cells. In: Tissue Antigens, Vol. 65, no. 2, p. 156-162 (2005)
Permanent URL http://hdl.handle.net/2078.1/39536