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Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds

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Yous, Saïd Lebegue, Nicolas Poupaert, Jacques [UCL] Chavatte, Philippe Berthelot, Pascal

Fifteen compounds derived from the 2( 3H)-benzothiazolone template with an acyl side-chain in position-6 were evaluated for their lipid-lowering action in mice. Among these compounds, 6-benzoyl-2( 3H)-benzothiazolone was found to be the most potent one both in mice models receiving a hypercholesterolemic diet ( for 15 days) or a standard diet ( for 21 days). 6-Benzoyl-2( 3H)-benzothiazolone compares favorably with fenofibrate, the standard drug, both in terms of HDL-C/Chol ( High Density Lipoprotein-Cholesterol/Total Cholesterol) ratio and absence of liver hepatomegaly.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 2005
Language Anglais
Journal information "Journal of Enzyme Inhibition and Medicinal Chemistry" - Vol. 20, no. 6, p. 525-532 (2005)
Peer reviewed yes
Publisher Taylor & Francis Ltd (Abingdon)
issn 1475-6366
e-issn 1475-6374
Publication status Publié
Affiliation UCL - MD/FARM - Ecole de pharmacie
Keywords 2(3H)-benzothiazolone ; cholesterol ; clofibrate ; fenofibrate ; normolipemic
Links
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Bibliographic reference Yous, Saïd ; Lebegue, Nicolas ; Poupaert, Jacques ; Chavatte, Philippe ; Berthelot, Pascal. Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds. In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 20, no. 6, p. 525-532 (2005)
Permanent URL http://hdl.handle.net/2078.1/38943