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The Euro-Lupus Nephritis Trial: the development of the sequential treatment protocol

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D'Cruz, D. P. Houssiau, Frédéric [UCL]

The treatment of lupus nephritis has evolved over many decades and cyclophosphamide has become the standard of care for proliferative lupus nephritis. This article describes the development of a protocol that utilises fixed low doses of cyclophosphamide followed sequentially by azathioprine as a maintenance agent, which has stood the test of time. As novel therapies and biologic agents are more widely used, it is likely that cyclophosphamide use will decline. In particular the prolonged high-dose regimen pioneered by the National Institutes of Health studies will no longer be used on account of its toxicity. Lupus (2009) 18, 875-877.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès restreint
Publication date 2009
Language Anglais
Journal information "Lupus" - Vol. 18, no. 10, p. 875-7 (2009)
Peer reviewed yes
Publisher Sage Publications Ltd (London)
issn 0961-2033
e-issn 1477-0962
Publication status Publié
Affiliations UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales
UCL - (SLuc) Service de rhumatologie
MESH Subject Lupus Nephritis - therapy ; Humans ; Clinical Trials as Topic
Keywords lupus nephritis ; low dose cyclophosphamide ; sequential therapy ; immunosuppression
Links
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Bibliographic reference D'Cruz, D. P. ; Houssiau, Frédéric. The Euro-Lupus Nephritis Trial: the development of the sequential treatment protocol. In: Lupus, Vol. 18, no. 10, p. 875-7 (2009)
Permanent URL http://hdl.handle.net/2078.1/35401