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From the neuromatrix to the pain matrix (and back)

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Iannetti, Gian Domenico [University College London] Mouraux, André [UCL]

Pain is a conscious experience, crucial for survival. To investigate the neural basis of pain perception in humans, a large number of investigators apply noxious stimuli to the body of volunteers while sampling brain activity using different functional neuroimaging techniques. These responses have been shown to originate from an extensive network of brain regions, which has been christened the Pain Matrix and is often considered to represent a unique cerebral signature for pain perception. As a consequence, the Pain Matrix is often used to understand the neural mechanisms of pain in health and disease. Because the interpretation of a great number of experimental studies relies on the assumption that the brain responses elicited by nociceptive stimuli reflect the activity of a cortical network that is at least partially specific for pain, it appears crucial to ascertain whether this notion is supported by unequivocal experimental evidence. Here, we will review the original concept of the "Neuromatrix" as it was initially proposed by Melzack and its subsequent transformation into a pain-specific matrix. Through a critical discussion of the evidence in favor and against this concept of pain specificity, we show that the fraction of the neuronal activity measured using currently available macroscopic functional neuroimaging techniques (e.g., EEG, MEG, fMRI, PET) in response to transient nociceptive stimulation is likely to be largely unspecific for nociception.

Document type Article de périodique (Journal article) – Synthèse de littérature – Journal Article, Research Support, Non-U.S. Gov't, Review
Access type Accès restreint
Publication date 2010
Language Anglais
Journal information "Experimental Brain Research" - Vol. 205, no. 1, p. 1-12 (2010)
Peer reviewed yes
Publisher Springer ((Germany) Heidelberg)
issn 0014-4819
e-issn 1432-1106
Publication status Publié
Affiliations UCL - SSS/IONS - Institute of NeuroScience
UCL - SSS/IONS/COSY - Systems & cognitive Neuroscience
MESH Subject Perception - physiology ; Pain Threshold - physiology ; Pain - pathology - physiopathology ; Nociceptors - physiology ; Neural Pathways - physiopathology ; Models, Neurological ; Humans ; Brain Mapping ; Brain - pathology - physiopathology ; Animals
Keywords Nociception ; Pain matrix ; Saliency ; Multimodal ; fMRI ; EEG
Links
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Bibliographic reference Iannetti, Gian Domenico ; Mouraux, André. From the neuromatrix to the pain matrix (and back). In: Experimental Brain Research, Vol. 205, no. 1, p. 1-12 (2010)
Permanent URL http://hdl.handle.net/2078.1/33674