Vantomme, Valérie
Boël, Pascale
Boon, Thierry
De Plaen, Etienne
[UCL]
van der Bruggen, Pierre
[UCL]
"Cancer-germline" genes such as those of the MAGE family are expressed in many tumors and in male germline cells, but are silent in normal tissues. They encode shared tumor-specific antigens, which have been used in therapeutic vaccination trials of cancer patients. MAGE-6 is expressed in more than 70% of metastatic melanomas and more than 50% of carcinomas of the lung, esophagus, bladder, and head and neck. We report here the identification of a new MAGE-6 antigenic peptide, which is recognized by a tumor-specific cytolytic T lymphocyte clone isolated from a melanoma patient. The peptide, ISGGPRISY, corresponds to positions 293 to 301 of the MAGE-6 protein sequence and is presented by HLA-Cw1601 molecules.
Bibliographic reference |
Vantomme, Valérie ; Boël, Pascale ; Boon, Thierry ; De Plaen, Etienne ; van der Bruggen, Pierre. A new tumor-specific antigenic peptide encoded by MAGE-6 is presented to cytolytic T lymphocytes by HLA-Cw16.. In: Cancer Immunity, Vol. 3, p. 17 (2003) |
Permanent URL |
http://hdl.handle.net/2078.1/29503 |