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Handedness, insulin sensitivity and pancreatic B-cell function in Type 2 diabetes.

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Hermans, Michel [UCL] Ahn, Sylvia [UCL] Selvais, Philippe Rousseau, Michel [UCL]

Background Laterality is associated with various health conditions. No study has addressed the influence of handedness on Type 2 diabetes mellitus (T2DM) phenotype, including glucose homeostasis, glucose-lowering therapies and metabolic control. Methods Five hundred and seventy-six consecutive adult T2DM outpatients underwent homeostasis model assessment (HOMA) of pancreatic B-cell function (B), insulin sensitivity (S), hyperbolic product (B x S) and age-standardized B x S deficit. Right-handed patients (87.5%; RH; n = 504) had similar age, gender, diabetes duration and education than non-right-handed patients (12.5%; non-RH; n = 72). Results Non-RH were more insulin-sensitive: 66% (39%) vs. 52% (36%) [mean (1 sd); P = 0.0024] and had significantly higher B x S and lower age-adjusted B x S deficit: 35% (20%) vs. 26% (17%) and 1.08% (0.40%) vs. 1.32% (0.55%)/year (non-RH; P = 0.0005 and P < 0.0001, respectively). Conclusions Non-right-handed T2DM patients are more insulin-sensitive, have higher hyperbolic product and less age-standardized B x S deficit. These may modulate glucose-lowering therapy requirements and glycaemic control.

Document type Article de périodique (Journal article) – Journal Article
Access type Accès restreint
Publication date 2009
Journal information "Diabetic medicine : a journal of the British Diabetic Association" - Vol. 26, no. 12, p. 1289-92 (2009)
Peer reviewed yes
issn 0742-3071
e-issn 1464-5491
Publication status Publié
Affiliations UCL - Cliniques universitaires Saint-Luc
UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de cardiologie
UCL - (SLuc) Service d'endocrinologie et de nutrition
MESH Subject Phenotype ; Models, Biological ; Middle Aged ; Male ; Insulin-Secreting Cells - metabolism - physiology ; Insulin Resistance - physiology ; Humans ; Homeostasis - physiology ; Hemoglobin A, Glycosylated - analysis ; Functional Laterality ; Female ; Diabetes Mellitus, Type 2 - physiopathology ; Cross-Sectional Studies ; Aged ; Adult
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Bibliographic reference Hermans, Michel ; Ahn, Sylvia ; Selvais, Philippe ; Rousseau, Michel. Handedness, insulin sensitivity and pancreatic B-cell function in Type 2 diabetes.. In: Diabetic medicine : a journal of the British Diabetic Association, Vol. 26, no. 12, p. 1289-92 (2009)
Permanent URL http://hdl.handle.net/2078.1/28897