Photoacoustic (PA) imaging uses a short-pulsed laser to create ultrasound signals for the high resolution acoustic imaging. The development of targeting PA contrast agents offers a unique opportunity to improve the early detection of cancer cells. This work aims to develop a silica coated iron oxide (SIO) nanoparticle as a potent cancer cell selective PA contrast agent, with a high binding affinity and selectivity to the gastrin releasing peptide receptor (GRPR) which is overexpressed in many human cancers including prostate cancer, breast cancer and small cell lung cancer etc.
Ma, Lixin ; Xu, Hang ; Lee, Li Ean ; Bandari, Rajendra P. ; Zhou, Thomas ; et. al. In vitro and in vivo evaluations of a high affinity and specificity photoacoustic nanoparticle targeting to cancer.2018 World Molecular Imaging Congress (Seattle, United States, du 12/09/2018 au 15/09/2018).
