User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Allergic contact dermatitis from transdermal buprenorphine.

Primary tabs

Vander Hulst, Kim Parera Amer, Elisabeth Jacobs, Claude Dewulf, Virginie Baeck, Marie [UCL] Tennstedt, Dominique [UCL] Goossens, An

BACKGROUND: Buprenorphine is a low-molecular-weight, lipophilic, opioid analgesic. The transdermal delivery system (TDS) containing it has skin irritation potential, but at least two cases of contact allergy to the active principal have been described previously. OBJECTIVE: To confirm allergic contact dermatitis from transdermal buprenorphine (TDB) in five older patients suffering from chronic pain and who developed persistent, pruritic erythematous plaques at the contact sites, with two of them also presenting with a generalized skin eruption. METHODS: Besides the baseline patch test series, all five patients were tested with the TDB, four of whom were also tested with the placebo transdermal delivery system as provided by the manufacturer; one patient was also tested with other preparations containing buprenorphine. RESULTS: All reacted to the TDB containing the active principal, the placebo being negative in the four patients tested. The patient tested with the other buprenorphine preparations did react positively to them as well. Tests with TDB in 28 healthy controls were negative. CONCLUSION: We report five cases of delayed hypersensitivity reactions to a TDS containing buprenorphine. Such adverse reactions might be under-reported. A fentanyl-containing TDS is a good alternative in these cases.

Document type Article de périodique (Journal article) – Case Reports, Journal Article
Access type Accès restreint
Publication date 2008
Language Anglais
Journal information "Contact dermatitis" - Vol. 59, no. 6, p. 366-9 (2008)
Peer reviewed yes
issn 0105-1873
e-issn 1600-0536
Publication status Publié
Affiliations UCL - MD/ESP - Ecole de santé publique
UCL - (SLuc) Service de dermatologie
MESH Subject Administration, Cutaneous ; Aged ; Aged, 80 and over ; Analgesics, Opioid - administration & dosage - adverse effects ; Buprenorphine - administration & dosage - adverse effects ; Dermatitis, Allergic Contact - diagnosis - etiology ; Erythema Nodosum - diagnosis - etiology ; Female ; Humans ; Male ; Middle Aged ; Pain - drug therapy ; Patch Tests - methods
Links
  1. Zuurmond, Acta Anaesthesiologica Belgica, 53, 193 (2002)
  2. Johnson, J Pain Symptom Manage, 29, 297 (2005)
  3. Griessinger, Curr Med Res Opin, 21, 1147 (2005)
  4. Bo¨hme K., Buprenorphine in a Transdermal Therapeutic System – A New Option, 10.1007/s100670200031
  5. Callejo Melgosa, Allergy, 60, 1217 (2005)
  6. Pérez-Pérez, Contact Dermatitis, 58, 310 (2008)
  7. Fernández-Redondo, Contact Dermatitis, 58 (2008)
  8. Schmid-Grendelmeier, Curr Med Res Opin, 22, 501 (2006)
  9. Hogen Esch, Contact Dermatitis, 54, 42 (2006)
  10. Waclawski, Contact Dermatitis, 33, 51 (1995)
  11. Condé-Salazar, Contact Dermatitis, 25 (1991)
  12. Rodríguez, Contact Dermatitis, 53 (2005)
  13. De Cuyper, Contact Dermatitis, 27, 220 (1992)
Bibliographic reference Vander Hulst, Kim ; Parera Amer, Elisabeth ; Jacobs, Claude ; Dewulf, Virginie ; Baeck, Marie ; et. al. Allergic contact dermatitis from transdermal buprenorphine.. In: Contact dermatitis, Vol. 59, no. 6, p. 366-9 (2008)
Permanent URL http://hdl.handle.net/2078.1/27973