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Adulteration of cocaine with levamisole: possible neurological complications

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Hantson, Philippe [UCL]

Hair testing reveals that cocaine is frequently adulterated with levamisole Blood determination of levamisole remains difficult, with a short half-life of 5.6 h The possible role of levamisole in inducing MIL or more particular brain lesions (Susac or Susac-like syndromes) remains speculative but further epidemiological investigations are required Atypical neurological presentation after cocaine use should be investigated by brain MRI Shorter duration of exposure and lower doses for MIL in comparison with vasculitis or agranulocytosis? Immunologic mechanism? Immunotherapy (steroids, immunoglobulin, plasmapheresis) may be beneficial in documented cases of MIL

Document type Communication à un colloque (Conference Paper) – Présentation orale avec comité de sélection
Access type Accès libre
Publication date 2022
Language Anglais
Conference "XVI Congrès Antidotes in Depht 2022", Pavia (du 28/09/2022 au 30/09/2022)
Affiliation UCL - SSS/IREC/MEDA - Pôle de médecine aiguë
Keywords Cocaine ; Levamisole ; neurological ; complications
Links
Bibliographic reference Hantson, Philippe. Adulteration of cocaine with levamisole: possible neurological complications .XVI Congrès Antidotes in Depht 2022 (Pavia, du 28/09/2022 au 30/09/2022).
Permanent URL http://hdl.handle.net/2078.1/273762