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Myometrial interstitial cells and the coordination of myometrial contractility.

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Hutchings, Graham [UCL] Williams, Olivia [UCL] Cretoiu, D [’Victor Babeüs, National Institute of Pathology, Bucharest, Romania] Ciontea, Sanda M [’Victor Babeüs, National Institute of Pathology, Bucharest, Romania]

Abstract A strict regulation of contractility in the uterus and fallopian tube is essential for various reproductive functions. The uterus contributes, through either increased contractility or periods of relative quiescence, to: (a) expulsion of menstrual debris; (b) sperm transport; (c) adequate embryo placement during implantation; (d) enlarging its capacity during pregnancy; (e) parturition. The dominant cell population of the uterine wall consists of smooth muscle cells that contain the contractile apparatus responsible for the generation contractile force. Recent interest has focused on a new population of cells located throughout the myometrium on the borders of smooth muscle bundles. These cells are similar to interstitial cells of Cajal (ICC) in the gut that are responsible for the generation of electrical slow waves that control peristalsis. A precise role for myometrial Cajal-like interstitial cells (m-ICLC) has not been identified. m-ICLC express the c-kit receptor, involved in creating and maintaining the ICC phenotype in the gastrointestinal tract. However, both acute and prolonged inhibition of this receptor with the c-kit antagonist imatinib mesylate does not appear to affect the spontaneous contractility of myometrium. Calcium imaging of live tissue slices suggests that contractile signaling starts on the borders of smooth muscle bundles where m-ICLC are located and recently the possible role of extracellular ATP signaling from m-ICLC has been studied. This manuscript reviews the evidence regarding tissue-level signaling in the myometrium with a particular emphasis on the anatomical and possible functional aspects of m-ICLC as new elements of the contractile mechanisms in the uterus.

Document type Article de périodique (Journal article) – Journal Article
Publication date 2009
Journal information "Journal of cellular and molecular medicine" - Vol. 13, no. 10, p. 4268-82 (2009)
Peer reviewed yes
issn 1582-1838
e-issn 1582-4934
Publication status Publié
Affiliation UCL - MD/GYPE - Département de gynécologie, d'obstétrique et de pédiatrie
MESH Subject Uterine Contraction - physiology ; Proto-Oncogene Proteins c-kit - metabolism ; Myometrium - cytology - physiology ; Models, Biological ; Interstitial Cells of Cajal - cytology ; Humans ; Female ; Animals ; Adenosine Triphosphate - metabolism
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Bibliographic reference Hutchings, Graham ; Williams, Olivia ; Cretoiu, D ; Ciontea, Sanda M. Myometrial interstitial cells and the coordination of myometrial contractility.. In: Journal of cellular and molecular medicine, Vol. 13, no. 10, p. 4268-82 (2009)
Permanent URL http://hdl.handle.net/2078.1/26290