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Genetic and acquired thrombotic factors in chronic hepatitis C.

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Poujol-Robert, Armelle Rosmorduc, Olivier Serfaty, Lawrence Coulet, Florence Poupon, Raoul Robert, Annie [UCL]

OBJECTIVES: During the progression of chronic liver disease towards cirrhosis, morphological studies have shown a close association between parenchymal remodeling and obliterative lesions of intrahepatic small portal and hepatic veins. These lesions are highly suggestive of intrahepatic thrombotic events, which may have a key role in the pathogenesis of hepatic fibrosis. The aim of the study was to investigate thrombotic risk factors in chronic hepatitis C patients with different extent of liver fibrosis. METHODS: The following thrombotic factors were evaluated in 68 hepatitis C patients with prothrombin activity >/= 80% (34 consecutive patients with extensive fibrosis and/or cirrhosis compared with 34 consecutive patients without extensive fibrosis and/or cirrhosis): factor V Leiden, G20210A prothrombin mutation, antithrombin, protein C and S deficiencies, hyperhomocysteinemia, elevated factor VIII level, and lupus anticoagulant. RESULTS: Three thrombotic risk factors were significantly more frequent in patients with extensive fibrosis and/or cirrhosis than in those without extensive fibrosis: protein C deficiency present in 14 patients (41%) as compared with three patients (9%), p= 0.004; elevated factor VIII level present in 19 patients (56%) as compared with six patients (18%), p= 0.002; and hyperhomocysteinemia present in 10 patients (29%) as compared with two patients (6%), p= 0.023. The association of two or three prothrombotic factors was present in 19 patients (56%) with extensive fibrosis and/or cirrhosis as compared with one patient (3%) without extensive fibrosis and/or cirrhosis, p < 0.001. CONCLUSION: Multiple thrombotic risk factors coexist frequently in patients with extensive fibrosis and early stage of cirrhosis. Their association with local inflammation could favor thrombotic events in the liver micro-circulatory bed.

Document type Article de périodique (Journal article) – Journal Article
Publication date 2004
Journal information "The American journal of gastroenterology" - Vol. 99, no. 3, p. 527-31 (2004)
Peer reviewed yes
issn 0002-9270
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
MESH Subject Adult ; Aged ; Antithrombins - analysis ; Factor VIII - analysis ; Female ; Hepatitis C, Chronic - blood - etiology - genetics ; Homocysteine - blood ; Humans ; Male ; Middle Aged ; Protein C - analysis ; Protein S - analysis ; Risk Factors ; Thrombosis - blood - complications - genetics
Links
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Bibliographic reference Poujol-Robert, Armelle ; Rosmorduc, Olivier ; Serfaty, Lawrence ; Coulet, Florence ; Poupon, Raoul ; et. al. Genetic and acquired thrombotic factors in chronic hepatitis C.. In: The American journal of gastroenterology, Vol. 99, no. 3, p. 527-31 (2004)
Permanent URL http://hdl.handle.net/2078.1/25837