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Salt wasting and blood pressure

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Devuyst, Olivier [UCL]

Recessive loss-of-function mutations in genes involved in renal NaCl handling cause rare diseases characterized by salt wasting and reduced blood pressure of variable severity. A new study shows that the carrier state for rare inactivating mutations in three genes involved in NaCl transport in the kidney is associated with a significant blood pressure reduction and a reduced risk of hypertension in the general population.

Document type Article de périodique (Journal article) – Article de recherche – Comment, News
Access type Accès restreint
Publication date 2008
Language Anglais
Journal information "Nature Genetics" - Vol. 40, no. 5, p. 495-496 (2008)
Peer reviewed yes
Publisher Nature Publishing Group ((United States) New York)
issn 1061-4036
e-issn 1546-1718
Publication status Publié
Affiliations UCL - MD/MINT - Département de médecine interne
UCL - (SLuc) Service de néphrologie
MESH Subject Bartter Syndrome - genetics ; Blood Pressure - genetics ; Genes, Recessive ; Gitelman Syndrome - genetics ; Heterozygote ; Humans ; Hypertension - genetics ; Kidney Tubules - metabolism ; Sodium Chloride - metabolism
Links
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Bibliographic reference Devuyst, Olivier. Salt wasting and blood pressure. In: Nature Genetics, Vol. 40, no. 5, p. 495-496 (2008)
Permanent URL http://hdl.handle.net/2078.1/25695