A novel synthetic strategy towards N-acyl sulfamates was developed. Interestingly, fluorosulfates, a new emerging class of electrophiles, were used to construct the sulfamate core. This precludes handling of chlorosulfonyl isocyanate and sulfamoyl chloride. In combination with amides, a wide and diverse set of N-acyl sulfamates was synthesized, including functionalized bioactive compounds. Furthermore, initial results showed that this method is also amenable to access N-thioacyl sulfamates.
Vangrunderbeeck, Sarah ; Gilles, Philippe ; et. al. Synthesis of N-Acyl Sulfamates from Fluorosulfates and Amides.Merck Organic Chemistry Symposium (MOCS) (Blankenberge, du 06/12/2018 au 07/12/2018).
