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Proteinuria: changes and mechanisms in toxic nephropathies.

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Bernard, Alfred [UCL] Lauwerys, Robert [UCL]

During the last few decades, considerable progress has been made in the understanding of the pathophysiological mechanisms of proteinuria. A great variety of hemodynamic or biochemical mechanisms acting at different sites of the nephron have been shown to alter the renal handling and the urinary excretion of proteins. The finding which perhaps has had most practical implications is that the pattern of protein excretion quantitatively and qualitatively varies with the site and severity of renal damage. This has led to the development of a large array of methods for the identification and quantitation of specific urinary proteins. These methods have been most extensively used by toxicologists in experimental, epidemiological, or clinical studies on potentially nephrotoxic chemicals (e.g., drugs, heavy metals, solvents, etc.). The present review summarizes the current state of knowledge on the mechanisms of proteinuria and the use of urinary proteins as indicators of nephrotoxicity.

Document type Article de périodique (Journal article) – Journal Article, Review
Publication date 1991
Journal information "Critical reviews in toxicology" - Vol. 21, no. 5, p. 373-405 (1991)
Peer reviewed yes
issn 1040-8444
Publication status Publié
Affiliation UCL - MD/ESP - Ecole de santé publique
MESH Subject Animals ; Humans ; Kidney Diseases - chemically induced - physiopathology ; Proteinuria - chemically induced - physiopathology
Links
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Bibliographic reference Bernard, Alfred ; Lauwerys, Robert. Proteinuria: changes and mechanisms in toxic nephropathies.. In: Critical reviews in toxicology, Vol. 21, no. 5, p. 373-405 (1991)
Permanent URL http://hdl.handle.net/2078.1/24743