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Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds.

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Léonard, Albert [UCL] Gerber, G B

The mutagenic, carcinogenic and teratogenic effects of vanadium and its compounds are reviewed. It is concluded that vanadium is not clastogenic and only weakly mutagenic; it has marked mitogenic activity affecting the distribution of chromosomes during mitosis and possibly causing aneuploidy. The few positive data on effects of vanadium during development leave it open whether direct effects on the embryo of fetus or physiological disturbances in the mother are responsible. No data exist indicating that vanadium is carcinogenic in animals or man, but since it interferes with mitosis and chromosome distribution, the possibility that vanadium might be carcinogenic under certain conditions cannot be dismissed offhand.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't, Review
Publication date 1994
Journal information "Mutation research" - Vol. 317, no. 1, p. 81-8 (1994)
issn 0027-5107
Publication status Publié
Affiliation UCL - MD/MIGE - Département de microbiologie, d'immunologie et de génétique
MESH Subject Animals ; Carcinogens - toxicity ; Humans ; Mutagens - toxicity ; Teratogens - toxicity ; Vanadium Compounds - toxicity
Links
Bibliographic reference Léonard, Albert ; Gerber, G B. Mutagenicity, carcinogenicity and teratogenicity of vanadium compounds.. In: Mutation research, Vol. 317, no. 1, p. 81-8 (1994)
Permanent URL http://hdl.handle.net/2078.1/24585