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Human megakaryocyte polyploidization is associated with a decrease in GPIIIA expression.

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Baatout, Sarah [UCL] Chatelain, Bernard [UCL] Staquet, Philippe [UCL] Symann, Michel [UCL] Chatelain, Christian [UCL]

Megakaryocytes are platelet forming cells and are characterized by polyploidization, a phenomenon by which nuclear division occurs without corresponding cytoplasmic separation. Among the markers allowing to identify megakaryocytes, glycoprotein (GP) IIIa with GPIb and GPIIb are the most important. Using GPIIIa as a marker to recognize megakaryocytes in the bone marrow, we have estimated GPIIIa expression by flow cytometry in megakaryocyte populations from normal individuals and from patients with chronic myelogenous leukemia, immune thrombocytopenic purpura or polycythemia vera. We showed that the expression of GPIIIa is decreasing during megakaryocyte polyploidization in normal and pathological situations.

Document type Article de périodique (Journal article) – Article de recherche
Access type Accès restreint
Publication date 1999
Journal information "Anticancer Research : international journal of cancer research and treatment" - Vol. 19, no. 6B, p. 5187-5189 (1999)
Peer reviewed yes
Publisher International Institute of Anticancer Research
issn 0250-7005
e-issn 1791-7530
Publication status Publié
Affiliations UCL - MD/BICL - Département de biochimie et de biologie cellulaire
UCL - MD/MINT - Département de médecine interne
UCL - (MGD) Laboratoire de biologie clinique
UCL - (MGD) Service d'hématologie
UCL - (SLuc) Unité d'oncologie médicale
MESH Subject Antigens, CD - metabolism ; Flow Cytometry ; Humans ; Integrin beta3 ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive - metabolism - pathology ; Megakaryocytes - metabolism - pathology ; Platelet Membrane Glycoproteins - metabolism ; Polycythemia Vera - metabolism - pathology ; Polyploidy ; Purpura, Thrombocytopenic - metabolism - pathology
Keywords Megakaryocyte ; Polyploidization ; GPIIIa ; Immune thrombocytopenic purpura ; Chronic myelogenous leukemia ; Polycythemia vera
Links
Bibliographic reference Baatout, Sarah ; Chatelain, Bernard ; Staquet, Philippe ; Symann, Michel ; Chatelain, Christian. Human megakaryocyte polyploidization is associated with a decrease in GPIIIA expression.. In: Anticancer Research : international journal of cancer research and treatment, Vol. 19, no. 6B, p. 5187-5189 (1999)
Permanent URL http://hdl.handle.net/2078.1/24112