User menu

Accès à distance ? S'identifier sur le proxy UCLouvain

Transforming growth factor beta as a neuronoglial signal during peripheral nervous system response to injury.

Primary tabs

Rogister, B. [UCL] Delrée, P. [UCL] Leprince, P. [UCL] Martin, D. [UCL] Sadzot, C. [UCL] Malgrange, B. [UCL] Munaut, C. [UCL] Rigo, J. M. [UCL] Lefebvre, P. P. [UCL] Octave, Jean-Noël [UCL]

In contrast to the central nervous system (CNS), the peripheral nervous system (PNS) displays an important regenerative ability which is dependent, at least in part, on Schwann cell properties. The mechanisms which stimulate Schwann cells to adapt their behavior after a lesion to generate adequate conditions for PNS regeneration remain unknown. In this work, we report that adult rat dorsal root ganglion (DRG) neurons are able, after a lesion performed in vivo or when they are dissociated and cultured in vitro, to synthesize transforming growth factor beta (TGF beta), a pleiotropic growth factor implicated in wound healing processes and in carcinogenesis. This TGF beta is tentatively identified as the beta-1 isoform. Adult rat DRG neurons release a biologically active form of TGF beta which is able to elicit multiple Schwann cell responses including a stimulation to proliferate. Moreover, purified TGF beta-1 produces a Schwann cell morphology alteration and decreases the secretion of tissue-type plasminogen activator (tPA) and enhances the secretion of plasminogen activator inhibitor (PAI) by Schwann cells. This generates conditions which are thought to favor a successful neuritic regrowth. Furthermore, purified TGF beta-1 stimulates type IV collagen mRNA expression in Schwann cells. This subtype of collagen is associated with the process of myelinization. Finally, TGF beta-1 decreases nerve growth factor (NGF) mRNA expression by Schwann cells, an effect which could participate in the maintenance of a distoproximal NGF gradient during nerve regeneration. We propose that neuronal TGF beta plays an essential role as a neuronoglial signal that modulates the response of Schwann cells to injury and participates in the successful regeneration processes observed in the PNS.

Document type Article de périodique (Journal article) – Journal Article, Research Support, Non-U.S. Gov't
Publication date 1993
Journal information "Journal of neuroscience research" - Vol. 34, no. 1, p. 32-43 (1993)
Peer reviewed yes
issn 0360-4012
Publication status Publié
Affiliation UCL - MD/FSIO - Département de physiologie et pharmacologie
MESH Subject Animals ; Cell Division - drug effects ; Cells, Cultured ; Culture Media ; Extracellular Matrix Proteins - metabolism ; Ganglia, Spinal - metabolism - pathology ; Immunohistochemistry ; Nerve Growth Factors - genetics ; Neuroglia - physiology ; Neurons - metabolism - physiology ; Peripheral Nerves - injuries - pathology - physiopathology ; Plasminogen Activators - metabolism ; Plasminogen Inactivators - metabolism ; RNA, Messenger - metabolism ; Rats ; Schwann Cells - metabolism - pathology ; Signal Transduction ; Transforming Growth Factor beta - metabolism - pharmacology - physiology
Links
  1. Baichwal, Proc Natl Acad Sci USA, 85, 1701 (1988)
  2. Barlow, EMBO J, 3, 2355 (1984)
  3. Baron-Van Evercooren, Dev Brain Res, 36, 101 (1987)
  4. Bottenstein, Proc Natl Acad Sci USA, 76, 514 (1979)
  5. Carey, J Cell Biol, 97, 473 (1983)
  6. Carey, J Cell Biol, 102, 2254 (1986)
  7. Chomczynski, Anal Biochem, 162, 156 (1987)
  8. Chu, Nucleic Acids Res, 10, 5925 (1982)
  9. Daniloff, J Cell Biol, 103, 929 (1986)
  10. Daston, J Cell Biol, 112, 1229 (1991)
  11. Davis, J Cell Biol, 110, 1353 (1990)
  12. Delrée, J Neurosci Res, 23, 198 (1989)
  13. Eccleston, J Neurosci Res, 24, 524 (1989)
  14. Flanders, Development, 113, 183 (1991)
  15. Hall, Neuropathol Appl Neurobiol, 12, 27 (1986)
  16. Heumann, J Cell Biol, 104, 1623 (1987a)
  17. Heumann, Proc Natl Acad Sci USA, 84, 8735 (1987b)
  18. Ignotz, Proc Natl Acad Sci USA, 82, 8530 (1986a)
  19. Ignotz, J Biol Chem, 261, 4337 (1986b)
  20. Jensen, J Neurocytol, 16, 681 (1987)
  21. Klebe, J Cell Biol, 43, 69a (1969)
  22. Kurkinen, Nature, 317, 177 (1985)
  23. Labourdette, J Cell Physiol, 144, 473 (1990)
  24. Laiho, J Cell Biol, 103, 2403 (1986a)
  25. Laiho, Exp Cell Res, 164, 399 (1986b)
  26. Lefebvre, Neuroreport, 2, 305 (1991)
  27. Leprince, Anal Biochem, 177, 341 (1989)
  28. Leprince, J Neurochem, 57, 665 (1991)
  29. Lindholm, Nature, 330, 658 (1987)
  30. Lindholm, Neuroreport, 1, 9 (1990)
  31. Longo, Brain Res, 309, 105 (1984)
  32. Massague, Proc Natl Acad Sci USA, 83, 8206 (1986)
  33. Massague, J Cell Physiol Suppl, 5, 43 (1987)
  34. Masui, Proc Natl Acad Sci USA, 83, 2438 (1988)
  35. Matsuoka, J Neurosci, 11, 3165 (1991)
  36. Meier, Nature, 342, 548 (1989)
  37. Merrill, Glia, 4, 327 (1991)
  38. Millan, Development, 111, 131 (1991)
  39. Miller, Mol Endocrinol, 3, 1926 (1989a)
  40. Miller, Mol Endocrinol, 3, 1108 (1989b)
  41. Monard, Cell Biol Int Rep, 9, 297 (1985)
  42. Monard, TINS, 11, 541 (1988)
  43. Moonen, Int J Dev Neurosci, 8, 118 (1990)
  44. Mustoe, Science, 237, 1333 (1987)
  45. Nichols, J Neurosci Res, 28, 134 (1991)
  46. Pellegrino, Brain Res, 341, 16 (1985)
  47. Pelton, J Cell Biol, 115, 1090 (1991)
  48. Pepper, J Cell Biol, 111, 743 (1990)
  49. Piras, J Cell Biol, 115/3, 1295 (1991)
  50. Raivich, Neuron, 7, 151 (1991)
  51. Ratner, J Cell Biol, 101, 744 (1985)
  52. Ridley, J Cell Biol, 109, 3419 (1989)
  53. Roberts A. B., Sporn M. B., The Transforming Growth Factor-βs, Peptide Growth Factors and Their Receptors I (1990) ISBN:9783642492976 p.419-472, 10.1007/978-3-642-49295-2_8
  54. Robertson, Neurosci Lett, 93, 107 (1988)
  55. Rogister, Glia, 3, 252 (1990)
  56. Sakai, Proc Natl Acad Sci USA, 87, 8378 (1990)
  57. Saksela, J Cell Biol, 105, 957 (1987)
  58. Schluesener, J Neuroimmunol, 27, 41 (1990)
  59. Schluesener, J Neurosci Res, 28, 310 (1991)
  60. Schmid, Development, 111, 117 (1991)
  61. Scott, Nature, 302, 538 (1983)
  62. Seyedin, J Biol Chem, 261, 5693 (1986)
  63. Solem, Biochem Biophys Res Commun, 172, 945 (1990)
  64. Sporn, Nature, 313, 745 (1985)
  65. Sporn, J Cell Biol, 105, 1039 (1987)
  66. Thompson, J Cell Biol, 108, 661 (1989)
  67. Toru-Delbauffe, J Neurochem, 54, 1056 (1990)
  68. Tucker, Science, 226, 705 (1984)
  69. Unsicker, Neuroscience, 44, 613 (1991)
  70. Van den Eijnden-Van Raaij A J M, Koornneef I, Van Oostwaard T M J, Feyen A, Kruijer W, De Laat S W, Van Zoelen E J J, Purification of a growth factor related to platelet-derived growth factor and a typeβtransforming growth factor secreted by mouse neuroblastoma cells. A general strategy for the purification of basic polypeptide growth factors, 10.1042/bj2570375
  71. Wikner, J Invest Dermatol, 95, 607 (1990)
  72. Willison, Brain Res, 444, 10 (1988)
Bibliographic reference Rogister, B. ; Delrée, P. ; Leprince, P. ; Martin, D. ; Sadzot, C. ; et. al. Transforming growth factor beta as a neuronoglial signal during peripheral nervous system response to injury.. In: Journal of neuroscience research, Vol. 34, no. 1, p. 32-43 (1993)
Permanent URL http://hdl.handle.net/2078.1/23010