Geboes, Karel
Jouret-Mourin, Anne
[UCL]
Inflammatory pathology of the distal small bowel is relatively common. Three major clinical situations can be considered: a normal-appearing ileumon endoscopy, isolated ileitis, and ileocolitis. Acute enteritis is usually infectious in origin. Histology is not the best method for the diagnosis of enteric infections,because most acute enteritides are non-specific histologically and stool cultures or stool examination has a higher diagnostic yield. Chronic enteritis is less common and most notably caused by chronic infections such as yersiniosis and tuberculosis, by drugs and, in the Western world, primarily by Crohn’s disease. Inflammation called “backwash ileitis” can be present in the terminal ileum in patients with UC. Terminal ileum endoscopy and biopsy are considered as the gold standard for the differential diagnosis of chronic enteritis. The presence of endoscopic lesions and/or a clinical presentation with inflammatory diarrhea are the major indications for a biopsy. As endoscopy is now more frequently performed, pathologists are more likely to receive small intestinal samples and have to know the different features and the possible differential diagnosis between these pathologies.


- McHugh Jonathan B., Appelman Henry D., McKenna Barbara J., The Diagnostic Value of Endoscopic Terminal Ileum Biopsies. CME, 10.1111/j.1572-0241.2007.01194.x
- Geboes K, Ectors N, D’Haens G, Rutgeerts P, Is Ileoscopy With Biopsy Worthwhile in Patients Presenting With Symptoms of Inflammatory Bowel Disease? : , 10.1111/j.1572-0241.1998.00201.x
- Riza Koksal Ali, Boga Salih, Alkim Huseyin, Ergun Meltem, Bayram Mehmet, Sakiz Damlanur, Ozdogan Osman, Altinkaya Engin, Alkim Canan, How does a biopsy of endoscopically normal terminal ileum contribute to the diagnosis? Which patients should undergo biopsy?, 10.3402/ljm.v9.23441
- Shah Raj J., Fenoglio-Preiser Cecilia, Bleau Brian L., Giannella Ralph A., Usefulness of colonoscopy with biopsy in the evaluation of patients with chronic diarrhea, 10.1111/j.1572-0241.2001.03745.x
- Magro F., Langner C., Driessen A., Ensari A., Geboes K., Mantzaris G.J., Villanacci V., Becheanu G., Nunes P. Borralho, Cathomas G., Fries W., Jouret-Mourin A., Mescoli C., de Petris G., Rubio C.A., Shepherd N.A., Vieth M., Eliakim R., European consensus on the histopathology of inflammatory bowel disease, 10.1016/j.crohns.2013.06.001
- Mojtahed Amirkaveh, Pai Reetesh K., Anderson Matthew W., Arber Daniel A., Longacre Teri A., Reactive Lymphoid Hyperplasia of the Terminal Ileum : A Benign (Lymphoma-like) Condition That May Harbor Aberrant Immunohistochemical Patterns or Clonal Immunoglobulin Heavy Chain Gene Rearrangements, 10.1097/01.pai.0000446497.93867.98
- OʼBrien Blake Hugh, McClymont Kelly, Brown Ian, Collagenous Ileitis : A Study of 13 Cases, 10.1097/pas.0b013e3182206ef5
- Marteau P, Lavergne-Slove A, Lemann M, Bouhnik Y, Bertheau P, Becheur H, Galian A, Rambaud J C, Primary ileal villous atrophy is often associated with microscopic colitis, 10.1136/gut.41.4.561
- Cuvelier C, Barbatis C, Mielants H, De Vos M, Roels H, Veys E, Histopathology of intestinal inflammation related to reactive arthritis., 10.1136/gut.28.4.394
- Chang Hye-Sook, Lee Don, Kim Jong Cheol, Song Hye-Kyung, Lee Hyun Ju, Chung Eun-Ju, Kim Tae Hyup, Park Hye-Won, Byeon Jeong-Sik, Yang Suk-Kyun, Choe Jae-Won, Isolated terminal ileal ulcerations in asymptomatic individuals: natural course and clinical significance, 10.1016/j.gie.2010.08.029
- Goldstein Neal S., Isolated Ileal Erosions in Patients With Mildly Altered Bowel Habits : A Follow-up Study of 28 Patients, 10.1309/4pk0g68m2g1l6x47
- Lengeling Randall W., Mitros Frank A., Brennan John A., Schulze Konrad S., Ulcerative ileitis encountered at ileo-colonoscopy: Likely role of nonsteroidal agents, 10.1016/s1542-3565(03)70031-7
- O’Donnell S, Crotty PL, O’Sullivan M, et al. Isolated active ileitis: is it a mild subtype of Crohn's disease? Inflamm Bowel Dis. 2013;19:1815–22.
- Courville Elizabeth L., Siegel Corey A., Vay Tegan, Wilcox Allison R., Suriawinata Arief A., Srivastava Amitabh, Isolated Asymptomatic Ileitis Does Not Progress to Overt Crohn Disease on Long-term Follow-up Despite Features of Chronicity in Ileal Biopsies : , 10.1097/pas.0b013e3181ad25b6
- DiLauro Steven, Crum-Cianflone Nancy F., Ileitis: When It is Not Crohn’s Disease, 10.1007/s11894-010-0112-5
- Hosoe Naoki, Ohmiya Naoki, Hirai Fumihito, Umeno Junji, Esaki Motohiro, Yamagami Hirokazu, Onodera Kei, Bamba Shigeki, Imaeda Hiroyuki, Yanai Shunichi, Hisamatsu Tadakazu, Ogata Haruhiko, Matsumoto Takayuki, Shinzaki Shinichiro, Yano Tomonori, Okita Yoshiki, Araki Toshimitsu, Saruta Masayuki, Ohtsuka Kazuo, Ozeki Keiji, Ueno Yoshitaka, Kurahara Koichi, Sasaki Makoto, Tsujikawa Tomoyuki, Naganuma Makoto, Hibi Toshifumi, Kanai Takanori, , Chronic Enteropathy Associated With SLCO2A1 Gene [CEAS]—Characterisation of an Enteric Disorder to be Considered in the Differential Diagnosis of Crohn’s Disease, 10.1093/ecco-jcc/jjx068
- LEVINE T.S., PRICE A.B., Obstructive enterocolitis: a clinico-pathological discussion, 10.1111/j.1365-2559.1994.tb00598.x
- Lamps L W, Infective disorders of the gastrointestinal tract, 10.1111/j.1365-2559.2006.02544.x
- Vantrappen G, Ponette E, Geboes K, et al. Yersinia enteritis and enterocolitis: gastroenterological aspects. Gastroenterology. 1977;72:220–7.
- Naktin J, et al. Yersinia enterocolitica and Yersinia pseudotuberculosis. Clin Lab Med. 1999;19:523–36.
- Aabakken Lars, Small-bowel side-effects of non-steroidal anti-inflammatory drugs : , 10.1097/00042737-199904000-00004
- Messmer Marcus, Upreti Sunita, Tarabishy Yaman, Mazumder Nikhilesh, Chowdhury Reezwana, Yarchoan Mark, Holdhoff Matthias, Ipilimumab-Induced Enteritis without Colitis: A New Challenge, 10.1159/000452403
- Théophile Hélène, David Xavier-Richard, Miremont-Salamé Ghada, Haramburu Françoise, Five cases of sprue-like enteropathy in patients treated by olmesartan, 10.1016/j.dld.2013.12.014
- Geboes K, Ectors N, D’Haens G, Rutgeerts P. In: Tytgat GNJ, Bartelsman JFWM, van Deventer SJH, editors. The value of ileal biopsies in the diagnosis of IBD: inflammatory bowel diseases. Dordrecht: Kluwer Academic Publishers; 1995. p. 115–21.
- Wright Nicholas A., Pike Christine, Elia George, Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells, 10.1038/343082a0
- Setaffy L, Osuna MJM, Plieschnegger W, et al. Cryptogenic multifocal ulcerous stenosing enteritis (CMUSE), and neuromuscular and vascular hamartoma (NMVH): two sides of the same coin? Endoscopy. 2015;47:1–4.
- Kobayashi, Ito, Nakagawa, Matsushita, Nishikimi, Sakurai, Nimura, Neutrophil and endothelial cell activation in the vasa vasorum in vasculo-Behçet disease : Neutrophil and endothelial cell activation, 10.1046/j.1365-2559.2000.00859.x
- Goldstein Neal, Dulai Mohanpal, Contemporary Morphologic Definition of Backwash Ileitis in Ulcerative Colitis and Features That Distinguish It From Crohn Disease, 10.1309/uaxmw3428pgn9hj3
- Haskell Henry, Andrews Charles W, Reddy Sarathchandra I, Dendrinos Klea, Farraye Francis A, Stucchi Arthur F, Becker James M, Odze Robert D, Pathologic Features and Clinical Significance of ???Backwash??? Ileitis in Ulcerative Colitis : , 10.1097/01.pas.0000176435.19197.88
Bibliographic reference |
Geboes, Karel ; Jouret-Mourin, Anne. Ileitis. In: Karel Geboes et Anne Jouret-Mourin, Colitis : a practical approach to colon biopsy interpretation, Springer 2018, p. 231-242 |
Permanent URL |
http://hdl.handle.net/2078.1/220178 |